Ganoderma lucidum Triterpenoid Extraction via Cyclodextrin Inclusion
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Solution Overview
Problem
Current methods for extracting Ganoderma lucidum extracts, such as hot water extraction and organic solvent extraction, face challenges in obtaining high concentrations of anti-aging triterpenoids safely and efficiently, with organic solvent methods being toxic and complex, and hot water methods yielding low active ingredient concentrations.
Innovation Solution
A method using an aqueous cyclodextrin solution, potentially combined with ultrasonic extraction, to conjugate and extract triterpenoids from Ganoderma lucidum, optimizing cyclodextrin type and ratio for high efficiency and safety, avoiding organic solvents and simplifying the process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If hot water extraction method is used, then the extraction process is simple and safe, but the concentration of anti-aging triterpenoid components is low
Solution Approach 1:
The patent introduces cyclodextrin as an intermediary substance that facilitates the extraction of triterpenoids from Ganoderma lucidum. Cyclodextrin acts as a mediator between the water extraction system and the hydrophobic triterpenoid components, enabling effective extraction using safe and simple hot water while achieving high triterpenoid concentration in the extract.
2Quantity of substance
If organic solvent extraction method is used, then the concentration of active ingredients is high, but the process becomes complex and toxic
Solution Approach 1:
The patent replaces organic solvents with cyclodextrin as an intermediary extraction agent. Cyclodextrin enables the extraction of high concentrations of active ingredients using only water, thereby maintaining high active ingredient concentration while eliminating the complexity and toxicity associated with organic solvent-based extraction processes.
3Quantity of substance
If organic solvent extraction method is used, then the concentration of active ingredients is high, but safety is compromised due to toxicity
Solution Approach 1:
The patent uses cyclodextrin as a non-toxic intermediary substance that enables safe extraction of high concentrations of active ingredients. Cyclodextrin serves as a bridge that allows effective extraction without introducing harmful organic solvents, thereby maintaining high active ingredient concentration while ensuring safety through the use of benign water and cyclodextrin.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method achieves a high concentration of triterpenoids in Ganoderma lucidum extracts, reducing costs and environmental impact, while providing a safe and effective anti-aging cosmetic composition that inhibits MMP-1 and collagenase, effectively reducing skin wrinkles and increasing skin elasticity.
Implementation Method 1
utilizes an extraction technique using an aqueous cyclodextrin solution... which utilizes the inclusion ability of cyclodextrin
Implementation Method 2
extraction technique using an aqueous cyclodextrin solution in combination with ultrasonic extraction
Data Source
AI summary
A method for preparing Ganoderma lucidum extract using an eco-friendly extraction technique is disclosed. A Ganoderma lucidum extract prepared thereby and a cosmetic composition containing the extract, and their uses are disclosed. The extraction technique use an aqueous cyclodextrin solution alone or in combination with ultrasonic extraction to afford a Ganoderma lucidum extract containing a high concentration of the effective ingredient triterpenoid.