Gastric Artery Embolization Pressure Modulation
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Solution Overview
Problem
Current gastric artery embolization methods face challenges in controlling flow and pressure, leading to non-targeted embolization and potential adverse events due to reflux of embolic agents into non-target vessels, which complicates the procedure and reduces efficacy.
Innovation Solution
A pressure modulating device, such as a microvalve filter or inflatable balloon catheter, is deployed to infuse embolizing agents into the fundus while preventing delivery to proximal and distal non-target vessels, utilizing unique flow and pressure dynamics to ensure targeted delivery through a modified Seldinger technique.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If embolic agent is infused into the left gastric artery to treat obesity, then therapeutic effect is achieved through reduced ghrelin and gastric motility, but embolic agent refluxes into non-target vessels causing adverse events
Solution Approach 1:
A pressure modulating device is introduced as an intermediary between the embolic agent and the vascular system. This device temporarily modifies pressure dynamics to direct embolic flow preferentially into non-target vessels during infusion, preventing reflux into target vessels while maintaining therapeutic effectiveness
Solution Approach 2:
The invention changes the pressure parameter dynamically during the embolization procedure. By temporarily increasing pressure in the left gastric artery system during embolic agent infusion, the method directs flow away from non-target vessels and reduces reflux, thereby preventing non-target embolization while maintaining therapeutic efficacy
2Ease of operation
If current embolization methods are used without pressure control, then procedure simplicity is maintained, but non-targeted embolization occurs reducing efficacy
Solution Approach 1:
The pressure modulating device serves as a mediator that automates pressure control during embolization. This intermediary system manages the complexity of pressure regulation, allowing the procedure to maintain simplicity in execution while achieving precise embolization through automated pressure modulation
Solution Approach 2:
The pressure modulating device operates autonomously to regulate pressure during embolization. The system self-adjusts pressure parameters to optimize embolic agent delivery, eliminating the need for complex manual pressure control while maintaining high precision in embolization targeting
Data Source
AI summary
A method of bariatric embolization includes deploying an intravascular pressure modulating device at a target location, operating the pressure modulating device to reduce pressure within the fundus, and infusing an embolizing agent into the fundus. Use of the pressure modulating device prevents delivery of the embolizing agent into proximal and distal non-target vessels. The method takes advantage of unique flow and pressure dynamics of the arterial vessels in the stomach.