Gastrointestinal Ultrasonic Developer Density Matching
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Solution Overview
Problem
Current gastrointestinal tract ultrasonic examination aided developers face challenges such as limited diagnostic effectiveness, stability issues, and difficulties in gas discharge, leading to artifacts and shortened examination windows due to viscosity and density mismatches in solid contrast particles.
Innovation Solution
A gastrointestinal tract ultrasonic examination aided developer is formulated with a specific ratio of silica particles modified by biocompatible polymers, combined with temperature-sensitive thickeners, osmotic pressure regulators, and defoamers, ensuring uniform density and viscosity changes with temperature to enhance imaging clarity and prolonged examination time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If solid contrast particles with mismatched density and viscosity are used, then the aided developer can be prepared, but stability issues and sedimentation occur
Solution Approach 1:
The patent modifies the density parameter of solid contrast particles by coating with polymers (polyethylene glycol, polyvinyl alcohol, or carboxymethyl cellulose) to match the density of the liquid medium (1.028-1.089 g/ml). This parameter matching prevents sedimentation and floating, ensuring stable suspension and uniform distribution throughout the examination window period.
Solution Approach 2:
The patent uses composite solid contrast particles consisting of a core material (silica, glass, or metal oxide) coated with polymer materials. This composite structure allows tuning of both density and surface properties to achieve optimal suspension characteristics and ultrasonic reflection, resolving the contradiction between stability and uniformity.
2Duration of action of moving object
If the aided developer remains in low viscosity state, then gas can be discharged easily, but the examination window period is shortened
Solution Approach 1:
The patent employs temperature-sensitive thickening agents (poloxamer 407, poloxamer 338, or carbomer) that dynamically change viscosity with temperature. At room temperature (20±0.2°C), the viscosity is low (≤100 mPa·s) allowing easy gas discharge, while at body temperature (37±0.2°C), the viscosity increases (≥500 mPa·s) to prolong the examination window period by preventing rapid emptying.
Solution Approach 2:
The temperature-sensitive thickeners undergo phase transition or conformational change with temperature, transforming from an extended random coil structure at low temperature (low viscosity) to a collapsed globule structure at high temperature (high viscosity). This phase transition enables the dual requirement of gas discharge and prolonged retention.
3Manufacturing precision
If silica particles are modified with biocompatible polymers, then density uniformity is achieved, but the manufacturing process becomes more complex
Solution Approach 1:
The patent controls the density parameter of solid contrast particles by selecting appropriate polymer coatings and particle sizes (75-120 meshes). The polymer coating thickness and composition are optimized to achieve the target density range (1.028-1.089 g/ml) without requiring complex multi-step manufacturing processes.
Solution Approach 2:
The patent applies different polymer coatings to the surface of solid particles while maintaining the core particle properties. This local modification approach achieves density uniformity and biocompatibility without fundamentally changing the entire manufacturing process, only adding a surface treatment step.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The developer provides a stable, uniform product that effectively discharges gas, reduces artifacts, and prolongs the examination window, optimizing ultrasonic image clarity and diagnostic efficacy.
Implementation Method 1
a density of the solid contrast is the same as that of the aided developer liquid, which is 1.028 g/ml-1.089 g/ml
Implementation Method 2
The silica particles are modified by using the biocompatible polymer, making the density thereof be the same as that of the aided developer liquid, and the floating or sinking does not occur during a storage process
Implementation Method 3
a viscosity of the aided developer is relatively low when the temperature is lower than the gel temperature, and the viscosity of the aided developer increases when the temperature is higher than the gel temperature
Implementation Method 4
a gel temperature of the aided developer is 20-30° C., a viscosity of the aided developer is relatively low when the temperature is lower than the gel temperature, and the viscosity of the aided developer increases when the temperature is higher than the gel temperature
Implementation Method 5
0.02-0.04 parts of defoamer
Implementation Method 6
gastrointestinal filling ultrasonic examination is a method for improving the internal environment of gastrointestinal ultrasonic imaging
Data Source
AI summary
Disclosed are a gastrointestinal tract ultrasonic examination aided developer and a preparation method therefor. The aided developer is mainly composed of a thickener, an osmotic pressure regulator, a solid contrast, a defoamer and a flavoring agent, wherein a density of the solid contrast is the same as that of aided developer liquid. The present disclosure adopts the solid contrast with a special particle size, making a distribution area present a more obvious homogeneous high echo after the aided developer reaches the stomach and intestine, and a good aided developing effect is achieved.