Gel Patch Adhesive Mass Stability via pH and Glycerin Ratios
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Solution Overview
Problem
Gel patches containing glycol salicylate suffer from low storage stability, which affects their ability to exhibit analgesic action over a long period.
Innovation Solution
A gel patch with an adhesive mass layer comprising glycol salicylate, a water-soluble polymer, water, and poly(methyl acrylate/2-ethylhexyl acrylate), where the glycerin content is 8 to 15 times that of glycol salicylate by mass and the pH is 4.7 to 5.1, enhancing storage stability and adhesion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If gel patch contains glycol salicylate with conventional adhesive mass composition, then analgesic action is provided, but storage stability of glycol salicylate deteriorates over time
Solution Approach 1:
The patent applies parameter changes by optimizing the pH of the adhesive mass to a specific range (4.5-5.5) and controlling the water content within 10-30%. These parameter adjustments create an environment that stabilizes glycol salicylate during storage while preserving its analgesic effectiveness after application, thus resolving the contradiction between storage stability and duration of action.
Solution Approach 2:
The patent uses composite materials by formulating an adhesive mass that combines multiple components including water-soluble polymers, natural resins, and synthetic resins in specific ratios. This composite adhesive mass provides both the stability needed to preserve glycol salicylate during storage and the effectiveness needed for prolonged analgesic action, thereby resolving the contradiction between storage stability and duration of action.
2Object-affected harmful factors
If gel patch uses thick adhesive mass with large moisture content, then skin irritation is reduced, but storage stability of glycol salicylate deteriorates
Solution Approach 1:
The patent applies parameter changes by precisely controlling the water content within 10-30% and pH within 4.5-5.5. This optimization maintains sufficient moisture to prevent skin irritation while creating a stable environment that prevents degradation of glycol salicylate during storage, thus resolving the contradiction between reducing skin irritation and maintaining storage stability.
Solution Approach 2:
The patent applies local quality by creating different functional zones within the adhesive mass through the use of composite materials with different properties. The formulation includes components that locally provide moisture retention to protect skin while other components locally provide stabilization of glycol salicylate, thereby resolving the contradiction between skin protection and storage stability.
3Reliability
If gel patch maintains low pH for storage stability, then adhesion force deteriorates over time
Solution Approach 1:
The patent uses composite materials by combining water-soluble polymers, natural resins, and synthetic resins in specific ratios within the adhesive mass. This composite formulation creates a synergistic effect where the combination of materials maintains both the low pH environment needed for glycol salicylate stability and the adhesion force required for effective patch performance, thus resolving the contradiction between storage stability and adhesion strength.
Solution Approach 2:
The patent applies universality by designing adhesive mass components that perform multiple functions simultaneously. The composite adhesive materials provide both pH buffering to maintain stability of glycol salicylate and adhesion promotion to maintain strong bonding, thereby resolving the contradiction between storage stability and adhesion force through multi-functional materials.
Data Source
AI summary
The present invention provides a gel patch comprising an adhesive mass layer on a backing fabric, wherein the adhesive mass layer contains glycol salicylate, a water-soluble polymer, water and glycerin, and the content of glycerin is 8 to 15 times the content of glycol salicylate on the basis of mass.