Gelatin-Cyclodextrin Tissue Adhesive Swelling Resistance
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Solution Overview
Problem
Tissue adhesives that use gelatin derivatives swell in physiological saline solutions, leading to potential peeling off from the application site and increased stress on biotissue, which compromises their effectiveness and durability.
Innovation Solution
A tissue adhesive comprising a gelatin derivative with a hydrophobic group bound through an imino group and cyclodextrin, combined with a crosslinking agent, which reduces swelling in physiological saline solutions and enhances pressure resistance strength.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If gelatin derivative adhesive is used to achieve good adhesion and biocompatibility, then adhesion strength and biocompatibility are improved, but the cured product swells in physiological saline solution causing peeling and increased stress on tissue
Solution Approach 1:
The patent uses a composite material system consisting of gelatin derivative (hydrophilic component) and cyclodextrin (hydrophobic component) to create an adhesive that maintains good adhesion and biocompatibility while resisting swelling in physiological saline solutions. The hydrophobic cyclodextrin molecules integrate with the hydrophilic gelatin network to provide swelling resistance without sacrificing adhesion performance.
2Reliability
If the adhesive absorbs fluid from physiological saline solution, then adhesion to biotissue is maintained, but the adhesive swells and peels off from the application site
Solution Approach 1:
The patent modifies the chemical composition parameters of the adhesive by incorporating cyclodextrin molecules with specific hydrophobic properties. This changes the adhesive's interaction with physiological saline, allowing it to maintain adhesion while preventing excessive fluid absorption and volume expansion that would lead to peeling.
3Stability of the object's composition
If the cured adhesive swells, then it may maintain flexibility, but it causes shearing stress at the interface between cured product and biotissue
Solution Approach 1:
The gelatin-cyclodextrin composite structure provides a balanced material property where the hydrophobic cyclodextrin components restrict excessive swelling while the hydrophilic gelatin maintains flexibility. This composite architecture reduces shearing stress at the tissue interface by preventing uncontrolled volume expansion.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive remains resistant to swelling and peeling, maintaining strong adhesion to biotissue while reducing stress on the applied area, making it suitable for use in wound dressing, anti-adhesion, hemostatic, and sealant applications.
Implementation Method 1
a gelatin derivative in which a hydrophobic group is bound to gelatin through an imino group and includes cyclodextrin
Implementation Method 2
a second agent that includes a crosslinking agent for the gelatin derivative
Data Source
AI summary
The adhesive includes a first agent that includes a gelatin derivative in which a hydrophobic group is bound to gelatin through an imino group represented by a formula 1: GltnNH-R1 and includes cyclodextrin; and a second agent that includes a crosslinking agent for the gelatin derivative. The cured product is resistant to swell in a physiological saline solution. In the formula 1, Gltn represents a residue of the gelatin, R1 represents the hydrophobic group, and NH represents the imino group binding to the residue and the hydrophobic group.