Crosslinked Gelatin Particles for Wet Tissue Adhesion

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Solution Overview

Problem

Current wound dressing materials for Endoscopic Submucosal Dissection (ESD) lack shape conformity, biodegradability, and adhesiveness to wet tissues, and their biodegraded products can cause tissue inflammation.

Innovation Solution

A wound dressing material comprising crosslinked gelatin derivative particles with a specific structure (GltnNH-CHR1< R2<), which are spray-dried and thermally crosslinked, providing high adhesiveness and biodegradability without the need for a dispersion medium or crosslinking agent.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of stationary object

If polyglycolic acid nonwoven fabric is used for wound dressing, then biodegradability is improved, but adhesiveness to wet tissues deteriorates

Engineering Contradiction:

ImprovebiodegradabilityVSAvoidadhesiveness to wet tissues

Core Design Contradiction:

Duration of action of stationary objectVSReliability

Solution Approach 1:

The invention uses a composite structure combining polyglycolic acid nonwoven fabric with gelatin derivative particles. The fabric provides biodegradability while the gelatin derivative particles provide adhesiveness to wet tissues, resolving the contradiction between these two properties.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The gelatin derivative particles are applied locally to the wound surface where adhesiveness is needed, while the polyglycolic acid fabric provides the biodegradable base structure. Each material performs its specialized function at the appropriate location.

Inventive Principle:

Principle #3Local quality

2Reliability

If fibrin adhesive is used to fix nonwoven fabric, then adhesiveness is improved, but cost and contamination risk increase

Engineering Contradiction:

ImproveadhesivenessVSAvoidcontamination risk and cost

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The gelatin derivative particles serve as a disposable, cost-effective adhesive alternative to expensive fibrin adhesive. The particles are applied directly to the wound and provide sufficient adhesion without the contamination risks associated with blood products.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The gelatin derivative particles inherently provide adhesiveness without requiring additional fixing agents. The material itself performs the adhesive function, eliminating the need for separate fibrin adhesive application.

Inventive Principle:

Principle #25Self-service

3Duration of action of stationary object

If nonwoven fabric is used for ESD wound dressing, then biodegradability is improved, but shape conformity deteriorates

Engineering Contradiction:

ImprovebiodegradabilityVSAvoidshape conformity

Core Design Contradiction:

Duration of action of stationary objectVSShape

Solution Approach 1:

The gelatin derivative particles can be sprayed to expand and conform dynamically to complex wound shapes, while the polyglycolic acid fabric provides the biodegradable base. The particle formulation allows the dressing to adapt to the wound geometry rather than requiring pre-shaping.

Inventive Principle:

Principle #15Dynamics

4Reliability

If gelatin particles with alkyl groups are used, then adhesiveness to wet tissues is improved, but manufacturing complexity increases

Engineering Contradiction:

Improveadhesiveness to wet tissuesVSAvoidmanufacturing process

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The gelatin derivative is modified by introducing alkyl groups at controlled ratios (20-80 mol%) to achieve optimal adhesiveness. This parameter adjustment allows tuning of the adhesive properties while maintaining a relatively simple manufacturing process through spray drying and heat treatment.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The wound dressing material can conform to complex wound shapes, exhibits high adhesiveness to wet tissues, and is biodegradable, reducing the risk of tissue inflammation and improving wound healing outcomes.

Implementation Method 1

A wound dressing material comprising a particle comprising crosslinked gelatin derivative

Methodology Applied

Scientific EffectSpray drying:

Implementation Method 2

The particle can be prepared without using a dispersion medium or a crosslinking agent to be applicable to the tissues without worrying about adverse effects caused by residues or decomposition products thereof

Methodology Applied

Scientific EffectThermal crosslinking:

Data Source

PatentEP3679954B1Wound dressing containing crosslinked gelatin derivative particles

Publication Date: 2025.03.05 NAT INST FOR MATERIALS SCI

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AI summary

A wound dressing material comprising a particle comprising a crosslinked gelatin derivative, the gelatin derivative comprising the structure represented by the following formula (1): GltnNH-CHR1R2 (1) wherein "Gltn" represents a gelatin residue, R1 represents an alkyl group having 1-17 carbon atoms, and R2 represents a hydrogen atom or an alkyl group having 1-17 carbon atoms, and the particle having a particle size ranging from 1 to 1,000 µm.