Genetic Feature Selection via Noise Vector Filtering

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Solution Overview

Problem

In biology, identifying associations between genetic features and traits is challenging due to underdetermined problems, where the number of genetic features exceeds the number of individuals, making it difficult to determine statistical associations and predict therapeutic interventions effectively.

Innovation Solution

A feature-selection technique that accesses genetic features and noise vectors for individuals, determines statistical associations, and selects a subset of genetic features based on aggregate properties, using supervised-learning techniques to provide predictive models for therapeutic interventions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If the number of genetic features is increased to improve trait association detection, then the completeness of genetic information is improved, but the problem becomes more underdetermined and computational complexity increases

Engineering Contradiction:
Improvetrait association detection accuracyVSAvoidcomputational complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent extracts and removes noise components from genetic feature data through statistical filtering. By separating signal from noise in the genetic data, the method reduces the effective dimensionality of the problem while preserving the meaningful associations between genetic features and traits, thereby reducing computational complexity without sacrificing detection accuracy.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent transforms the original genetic feature parameters by applying statistical operations and noise filtering. This parameter transformation converts the underdetermined problem with many features into a more manageable form where the effective number of independent parameters is reduced, allowing accurate association detection with lower computational complexity.

Inventive Principle:
Principle #35Parameter changes

2Quantity of substance

If the number of genetic features exceeds the number of individuals, then more comprehensive genetic coverage is achieved, but statistical association determination becomes difficult

Engineering Contradiction:
Improvegenetic feature coverageVSAvoidstatistical association determination
Core Design Contradiction:
Quantity of substanceVSMeasurement precision

Solution Approach 1:

The patent introduces noise vectors as an intermediary element to model the relationship between genetic features and traits. By incorporating explicit noise terms in the statistical model, the method can properly account for the excess features and determine significant associations even when the number of genetic features exceeds the number of individuals, maintaining statistical rigor.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces traditional mechanical statistical methods with a noise-filtering approach based on statistical signal processing. Instead of relying on conventional methods that struggle with p > n problems, the invention uses statistical operations to filter noise and identify significant associations, enabling accurate determination even with more features than samples.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Reliability

If all genetic features are analyzed to ensure no associations are missed, then detection completeness is improved, but computational resources and time are excessively consumed

Engineering Contradiction:
Improvedetection completenessVSAvoidcomputational efficiency
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The patent applies partial action by focusing computational resources on identifying the most significant genetic feature associations rather than exhaustively analyzing all possible features. Through noise filtering and statistical prioritization, the method achieves reliable detection of meaningful associations while avoiding the excessive computational burden of complete enumeration, thus improving efficiency without sacrificing essential completeness.

Inventive Principle:
Principle #16Partial or excessive action

Data Source

PatentUS20240331800A1Technique for Identifying Features
Publication Date: 2024.10.03 EXSANO INC
  • US20240331800A1 patent drawing
  • US20240331800A1 patent drawing
  • US20240331800A1 patent drawing

AI summary

During a feature-selection technique, an electronic device calculates combinations of features and noise vectors, where a given combination corresponds to a given feature and a given noise vector. Then, the electronic device determines statistical associations between information specifying types of events and the combinations, where a given statistical association corresponds to the types of events and a given combination. Moreover, the electronic device identifies a noise threshold associated with the combinations. Next, for a group of combinations having statistical associations equal to or greater than the noise threshold, the electronic device selects a subset of the features based at least in part on a first 10 aggregate property of the group of combinations, where the first aggregate property comprises numbers of occurrences of the features in the group of combinations.