Genome Anonymization via Segmentation and Linkage Records
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Solution Overview
Problem
Existing technologies are poorly equipped to manage and process genome sequences and associated information in a way that prevents individual identification and minimizes discrimination, particularly in compliance with regulations like HIPAA.
Innovation Solution
The development of methods and systems that segment genome sequences, use anchor segments to minimize storage space, generate linkage records and anonymized linkage records, and process genetic study results to maintain anonymity and prevent discrimination.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If genome sequences and associated information are stored and processed in databases for genetic studies, then research capabilities and personalized medicine applications are improved, but privacy breaches and individual identification risks increase
Solution Approach 1:
The patent divides genome sequences into segments and associates them with linkage records that point to organizational units containing associated information. This segmentation isolates genetic data from identifying information, allowing research while preventing re-identification. The linkage records create a layered structure where genome segments are separated from personal identifiers.
Solution Approach 2:
The patent introduces linkage records as intermediary elements between genome segments and associated information. These linkage records act as mediators that enable access to genetic data without exposing identifying information. The organizational units serve as intermediate containers that hold associated information separately from the genome sequences.
2Productivity
If linkage records are generated to associate genome segments with organizational units, then data organization and access efficiency are improved, but system complexity increases
Solution Approach 1:
The patent segments the data structure into distinct components: linkage records, organizational units, and genome segments. This segmentation allows each component to serve a specific function and simplifies the overall system by breaking down complex data relationships into manageable pieces that can be processed independently.
Solution Approach 2:
The linkage records serve multiple functions: they associate genome segments with organizational units, enable efficient data access, maintain privacy by separating identifying information, and support various types of queries. This multi-functionality reduces the need for separate systems and simplifies the overall architecture.
Data Source
AI summary
Various methods and systems for processing at least some of genome sequences and at least some of associated information, for an individual, may include one or more of: segmenting genome sequences for at least a purpose of anonymizing genome information; using anchor segments for a purpose of minimizing electronic storage space in storing of genetic sequence information; generating at least one linkage record; generating at least one anonymized linkage record; processing a request for genetic study results; processing genetic study results received; and/or generating personalized information of interest pertaining to the individual. A purpose of such processing may be to prevent, minimize, and/or mitigate against (1) identification of the individual from such genome sequence information and/or from associated information; and/or (2) using such genome sequence information and/or associated information as a basis for discriminating against the individual.