Conditional Germline Expression System for Insect Sterility

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Solution Overview

Problem

Current methods for sterilizing insects for pest control, such as radiation-sterilization in the sterile insect technique, cause damage to released insects and have limitations due to the need for large, costly equipment and security concerns, while alternative methods like chemo-sterilization and Wolbachia-based systems have their own disadvantages, necessitating a more effective and controlled genetic sterilization approach.

Innovation Solution

A conditional expression system in male arthropods that uses a bipartite expression system with a transcription factor and effector gene, allowing for controlled genetic sterility by producing sperm that are defective in fertilization but still competitive, mimicking the effects of radiation without its drawbacks.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If radiation-sterilization is used to sterilize insects for SIT, then sterilization effectiveness is improved, but insect performance (longevity, mating competitiveness) deteriorates

Engineering Contradiction:
Improvesterilization effectivenessVSAvoidinsect performance damage
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent extracts the sterilization function from radiation and transfers it to a genetic system. A dominant lethal gene is introduced into the insect genome, which is activated only in the germline to produce a toxic protein that kills sperm. This separates the sterilization mechanism from the harmful radiation effects on somatic cells, achieving sterilization without damaging the insect's overall performance.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent uses a conditional expression system as an intermediary between the lethal gene and the germline. The system includes a promoter that is activated only in germline cells and a repressor protein that can be controlled externally. This intermediary mechanism ensures the toxic protein is produced only where needed (in sperm) and only when needed, avoiding harmful effects on other tissues while maintaining sterilization effectiveness.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If radiation-sterilization equipment is deployed for SIT programs, then sterilization capability is improved, but device cost and complexity increase

Engineering Contradiction:
Improvesterilization capabilityVSAvoidirradiation equipment
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent replaces the mechanical radiation sterilization system with a biological genetic system. Instead of using expensive irradiation equipment to sterilize insects, the invention uses a genetically engineered dominant lethal gene that automatically sterilizes the insect through its own reproductive process. This substitution eliminates the need for complex irradiation equipment while maintaining sterilization capability.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The genetically modified insects perform their own sterilization through their reproductive process. When the dominant lethal gene is expressed in the germline, it produces a toxic protein that kills the sperm during spermatogenesis. The insect essentially sterilizes itself through its own genetic programming, eliminating the need for external sterilization equipment and processes.

Inventive Principle:
Principle #25Self-service

3Reliability

If chemo-sterilization is used to sterilize insects, then sterilization effectiveness is improved, but worker and environmental safety deteriorates

Engineering Contradiction:
Improvesterilization effectivenessVSAvoidworker and environmental safety
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies the toxic effect locally only to the germline cells that produce sperm. The conditional expression system ensures the toxic protein is produced exclusively in the germline through germline-specific promoters and regulatory elements. This localized application achieves sterilization effectiveness while avoiding exposure of workers and the environment to toxic chemicals, as the toxin is confined to the insect's reproductive tissue.

Inventive Principle:
Principle #3Local quality

4Reliability

If Wolbachia-based sterilization is used, then sterilization effectiveness is improved, but sex-separation complexity increases

Engineering Contradiction:
Improvesterilization effectivenessVSAvoidsex-separation requirements
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent segments the sterilization function from sex determination. The dominant lethal gene system operates independently in both male and female germlines, sterilizing them through the same mechanism. This segmentation eliminates the need for complex sex-separation procedures required by Wolbachia systems, as the sterilization mechanism works universally across sexes without requiring differential handling or additional separation infrastructure.

Inventive Principle:
Principle #1Segmentation

Data Source

PatentEP2823047B1biocontrol
Publication Date: 2018.05.09 OXITEC LTD
  • EP2823047B1 patent drawingFigure 1~2
  • EP2823047B1 patent drawingFigure 3~4
  • EP2823047B1 patent drawingFigure 5~6

AI summary

Provided is an arthropod male germline gene expression system suitable for conditional expression of an effector gene in an Arthropod male germline. The system comprises a first expression unit comprising an effector gene and a promoter therefor operably linked thereto; and a second expression unit. Said second unit comprises a coding sequence for a transcription factor and an upstream regulatory element operably linked thereto, the transcription factor being capable of acting upon the promoter in the first expression unit to drive expression of the effector gene. The upstream regulatory element includes a promoter for the transcription factor; and a 5' UTR adjacent a start site for the transcription factor coding sequence. The upstream regulatory element driving sufficient expression of the transcription factor such that the transcription factor protein in turn drives transcription of the effector gene before meiosis. Also provided are uses of the system for instance in methods of biocontrol and quality control.