GHG from Kenyan Purple Tea as AMPK Activator
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Solution Overview
Problem
Current AMPK activators, such as synthetic chemicals, have side effects and are difficult to use in foods, necessitating a safer and more effective alternative for activating AMPK to improve health by increasing muscle mass and reducing fat.
Innovation Solution
The use of 1,2-di-O-galloyl-4,6-O—(S)-hexahydroxydiphenoyl-β-D-glucose (GHG) derived from Kenyan purple tea (Camellia sinensis, variety TRFK306) as an AMPK activating agent, extracted using polar solvents and concentrated for administration in foods, drinks, and cosmetics.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If synthetic chemical AMPK activators (e.g., AICAR, metformin) are used, then AMPK activation and health improvement effects are achieved, but side effects occur and they are difficult to use in foods
Solution Approach 1:
The patent replaces expensive synthetic chemical AMPK activators with a naturally occurring compound (GHG from purple tea) that can be safely consumed through food and drink. The natural compound achieves the same AMPK activation effect without the harmful side effects of synthetic agents, making it suitable for long-term dietary use.
Solution Approach 2:
The patent uses GHG as an intermediary substance that mediates between dietary intake and AMPK activation. Instead of directly administering synthetic chemicals, the compound is extracted from purple tea and incorporated into food and drink products, serving as a safe intermediary that delivers the desired physiological effect without toxicity.
2Reliability
If synthetic chemical AMPK activators are used, then AMPK activation is achieved, but they are difficult to use in foods and drinks
Solution Approach 1:
The patent changes the chemical parameter from synthetic compounds to a natural compound (GHG) that has suitable properties for food incorporation. The compound is extracted from purple tea using polar solvents and concentrated to achieve the desired potency while maintaining compatibility with food and drink matrices.
Solution Approach 2:
The patent extracts the active compound GHG from purple tea using polar solvents and concentrates it to create a usable form for food and drink applications. This extraction process isolates the beneficial compound while removing unwanted components, enabling versatile incorporation into various food products.
3Object-affected harmful factors
If natural compounds are used as AMPK activators, then side effects are reduced and food applicability improves, but the activating effect must be sufficiently strong
Solution Approach 1:
The patent concentrates the GHG compound to achieve high local potency in the active ingredient while maintaining safety in the overall food product. The extraction and concentration process creates a purified form of the compound that delivers strong AMPK activation at appropriate dosages without the side effects of synthetic chemicals.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
GHG effectively activates AMPK, enhancing muscle endurance and reducing fat, with potential applications in obesity prevention and health improvement while minimizing side effects.
Implementation Method 1
extracting GHG in the solvent by immersing Kenyan purple tea (scientific name: Camellia sinensis, variety name: TRFK306) in a polar solvent
Data Source
AI summary
An AMP-activated protein kinase (AMPK) activating agent comprises 1,2-di-O-galloyl-4,6-O—(S)-hexahydroxydiphenoyl-b-D-glucose (“GHG”) as an active ingredient. The AMPK activating agent can be a GHG-containing composition wherein the GHG is an active ingredient of the composition. The GHG-containing composition can be derived from Kenyan purple tea, whose scientific name is Camellia sinensis, variety name: TRFK306. An effective amount of the GHG can be administered to a cell to activate the AMPK. Drinks, foods, and cosmetics can have the GHG as an active ingredient.