Endoscope-Nested LED Device for GI Photobiomodulation

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Solution Overview

Problem

Current technologies lack a non-invasive method to deliver photobiomodulation therapy (PBMT) directly to the gastrointestinal (GI) tract and adipose tissue, where it can effectively rebalance the microbiome and repair damaged mitochondria, thereby treating various metabolic and inflammatory diseases.

Innovation Solution

Development of battery-enabled LED light source devices deployable through an endoscope and anchored to the GI tract, utilizing red or near-infrared light to activate cytochrome c oxidase and opsins, promoting mitochondrial health and reducing chronic inflammation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If battery-enabled LED light source devices are deployed through an endoscope and anchored directly to the GI tract, then PBMT can be delivered directly to the GI tract and adipose tissue to rebalance the microbiome and repair damaged mitochondria, but the device complexity and difficulty of deployment increase

Engineering Contradiction:

Improveeffectiveness of PBMT deliveryVSAvoiddevice complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The PBMT device is nested within the endoscope for deployment. The battery-enabled LED light source device is delivered through the endoscope's working channel and then deployed into the GI tract, allowing minimally invasive access while maintaining device functionality. This nesting approach enables direct PBMT delivery to the GI tract and adipose tissue without requiring separate surgical procedures.

Inventive Principle:

Principle #7Nested doll (Nesting)

Solution Approach 2:

The endoscope serves as an intermediary tool for deploying the PBMT device. Rather than requiring direct surgical implantation, the endoscope facilitates the minimally invasive delivery of the battery-enabled LED device to the target site in the GI tract, reducing patient trauma and recovery time while ensuring proper device placement.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Ease of operation

If minimally invasive treatment methods are used to deliver PBMT to the GI tract, then recovery times and patient discomfort are reduced, but the ease of operation and deployment difficulty increase

Engineering Contradiction:

Improvepatient recoveryVSAvoiddeployment difficulty

Core Design Contradiction:

Ease of operationVSDevice complexity

Solution Approach 1:

Inventive Principle:

Principle #7Nested doll (Nesting)

3Reliability

If LED light sources are used to deliver red or near-infrared light for PBMT, then mitochondrial function is enhanced and chronic inflammation is reduced, but the power requirements and energy consumption increase

Engineering Contradiction:

Improvemitochondrial repair effectivenessVSAvoidenergy consumption

Core Design Contradiction:

ReliabilityVSUse of energy by moving object

Solution Approach 1:

The device utilizes LEDs that emit specific wavelengths of light (red or near-infrared) optimized for photobiomodulation therapy. By selecting appropriate wavelengths that match the absorption spectra of cytochrome c oxidase and opsins, the device maximizes therapeutic effectiveness while minimizing energy consumption. The battery is sized to provide sufficient power for the required treatment duration at these optimized parameters.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for minimally invasive treatment of diseases like obesity, diabetes, inflammatory bowel disease, and neurodegenerative disorders by enhancing mitochondrial function and signaling, reducing recovery times, patient discomfort, and treatment costs.

Implementation Method 1

Light in this spectrum activates cytochrome c oxidase (CCO), which is unit IV of the mitochondrial respiratory chain. When CCO absorbs light, the enzyme activity is increased leading to increased electron transport, more oxygen consumption, higher mitochondrial membrane potential, and increased ATP production

Methodology Applied

Scientific EffectPhotobiomodulation: Absorption (EM radiation)

Implementation Method 2

light actives nonvisual phototransduction cascades involving opsins. Blue light (415 nm) and green light (540 nm) are absorbed by opsins resulting in transient receptor potential (TRP) calcium ion channels activation

Methodology Applied

Scientific EffectPhototransduction: Photoelectric Effect

Data Source

PatentUS20230027861A1Photobiomodulation of the gastrointestinal tract

Publication Date: 2023.01.26 TARGET BRANDS INC

AI summary

Devices, systems, and methods can be used to deliver photobiomodulation therapy (PBMT) to the GI tract. For example, this document describes battery-enabled LED light source devices that can be deployed through or over an endoscope and anchored directly to the GI tract. Significant systemic effects can be produced by PBMT with application to one part of the body promoting beneficial anti-inflammatory and metabolic benefits in other remote sites promoted by enhanced mitochondrial function and mitokine signaling.