GI Sampling Tube for Representative, Low-Contamination Fluid Collection
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Solution Overview
Problem
There is a need for a safe, non-invasive method to routinely sample gastrointestinal fluids in a manner that captures a representative cross-section of the GI tract, prevents cross-contamination, and maintains the natural environment of the samples, while being comfortable for the subject.
Innovation Solution
A device comprising a sampling tube with a distal end in the GI tract and a proximal end outside the body, connected to a reservoir, which collects samples via inlet holes, and includes features like a head element to enhance peristalsis, a control unit for fluid/gas flow, and a reservoir for storing samples in a linear array, ensuring minimal contamination and comfort.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a sampling device is introduced into the GI tract to collect samples, then sample collection capability is improved, but subject comfort and safety deteriorate due to invasiveness
Solution Approach 1:
The patent employs a flexible sampling tube that can be swallowed and navigated through the GI tract, replacing rigid invasive instruments with a soft, compliant structure that conforms to the natural anatomy of the digestive system, thereby reducing discomfort while maintaining sampling capability
Solution Approach 2:
The device utilizes the body's own peristaltic movements to propel the sampling tube through the GI tract and deliver samples to the collection chamber, eliminating the need for external mechanical propulsion or additional invasive procedures
2Measurement precision
If continuous sampling is performed throughout the GI tract, then representativeness of samples is improved, but risk of cross-contamination between different GI regions increases
Solution Approach 1:
The sampling tube is divided into multiple discrete sampling ports positioned at different locations along its length, allowing samples from different GI regions to be collected separately in distinct chambers, preventing cross-contamination while maintaining comprehensive coverage
Solution Approach 2:
The patent introduces a sterile barrier or valve mechanism that acts as an intermediary between sampling ports, preventing direct communication between luminal contents at different locations and ensuring sample integrity
3Adaptability or versatility
If multiple samples are collected from different GI regions, then comprehensiveness of analysis is improved, but device complexity increases
Solution Approach 1:
The sampling tube serves multiple functions simultaneously: it acts as both the delivery vehicle for the stimulus agent and the collection instrument for gastrointestinal samples, eliminating the need for separate devices and reducing overall system complexity
Solution Approach 2:
The patent combines the stimulus agent delivery function and sample collection function into a single integrated device, merging what would traditionally require separate instruments into one unified system that performs both tasks
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device allows for continuous, representative sampling of gastrointestinal fluids while maintaining their natural state, preventing cross-contamination, and ensuring subject comfort, facilitating routine medical analysis.
Implementation Method 1
a head element to enhance peristalsis
Data Source
AI summary
Embodiments of devices and methods for sampling gastrointestinal fluids and assessing gastrointestinal function using a device comprising a sampling tube are provided.