Ginger Oleoresin Micellar Formulation for Solubility
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Solution Overview
Problem
Ginger's poor water solubility and rapid metabolism limit its bioavailability and effectiveness in treating gastrointestinal disorders, due to its rapid systemic elimination and poor absorption.
Innovation Solution
A composition comprising ginger oleoresin or gingeroids combined with gum Arabic and at least one saponin, such as quillaja extract, which enhances water solubility and stability at physiological pH, providing a slow release of gingeroids, thereby increasing bioaccessibility and bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If ginger oleoresin is used to increase gingeroid concentration, then bioefficacy is improved, but water solubility deteriorates
Solution Approach 1:
The patent uses saponins as intermediary substances that form mixed micelles with ginger oleoresin. These saponins act as mediators between the hydrophobic gingeroids and the aqueous environment, enabling solubilization without compromising the active ingredients. The saponins create a micellar structure that encapsulates the ginger oleoresin, making it water-soluble while maintaining bioefficacy.
Solution Approach 2:
The invention creates a composite formulation combining ginger oleoresin with saponins and phospholipids. This composite material leverages the properties of each component: ginger oleoresin provides the active gingeroids, saponins provide solubilization capability, and phospholipids enhance membrane permeability. The synergistic combination resolves the contradiction between concentration and solubility.
2Reliability
If ginger is administered to treat gastrointestinal disorders, then therapeutic effect is improved, but absorption is reduced due to rapid metabolism
Solution Approach 1:
The patent applies preliminary protection by encapsulating gingeroids in micelles formed by saponins and phospholipids before administration. This pre-encapsulation protects the gingeroids from rapid metabolism and degradation in the gastrointestinal tract, allowing them to reach their target sites intact and improving absorption efficiency.
Solution Approach 2:
The invention changes the physical-chemical parameters of gingeroid delivery by forming micellar structures with specific size ranges (50-500 nm). This size parameter optimization enhances penetration through biological membranes and protects against metabolic degradation, thereby improving both absorption and therapeutic effect.
3Reliability
If ginger oleoresin is used to maximize gingeroid content, then bioactivity is improved, but stability at physiological pH deteriorates
Solution Approach 1:
Phospholipids serve as intermediary substances that stabilize the micellar structure at physiological pH. They form a protective barrier around the ginger oleoresin core, preventing pH-induced degradation while maintaining the structural integrity necessary for bioactivity. The phospholipid head groups interact favorably with the aqueous environment at physiological pH, ensuring stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves a slow and prolonged release of gingeroids, increasing their half-life and bioavailability, allowing for improved absorption and efficacy in treating gastrointestinal disorders.
Implementation Method 1
a composition comprising ginger oleoresin or gingeroids, a gum (such as gum Arabic) and at least one saponin
Implementation Method 2
provides a slow release of the gingeroids, is highly water soluble and stable at physiological pH
Implementation Method 3
gum Arabic and at least one saponin (such as an extract obtained from or obtainable from quillaja), provides a slow release of the gingeroids, is highly water soluble
Data Source
AI summary
The present invention relates to compositions comprising gingeroids or ginger oleoresin; in particular, compositions comprising gingeroids or ginger oleoresin that are highly water soluble and have an increased bioavailability. The present invention also relates to processes for providing such compositions and uses of such compositions.