Gingerol Extract Capsules for Chemotherapy Nausea
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Solution Overview
Problem
Current antiemetics for chemotherapy-induced nausea and vomiting are ineffective for delayed post-chemotherapy nausea and often associated with significant adverse effects, with no pharmacologic agents successfully treating anticipatory nausea and vomiting.
Innovation Solution
A composition of ginger rhizome extract with specific ratios of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol, formulated into a drug delivery system using supercritical, critical, or near-critical fluids, providing an effective treatment for nausea and emesis with minimal adverse effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current antiemetics (5-HT3 receptor antagonists) are used to treat chemotherapy-induced nausea and vomiting, then emesis is better controlled, but nausea (especially delayed post-chemotherapy nausea) remains poorly controlled and significant adverse effects occur
Solution Approach 1:
The patent changes the chemical parameters by using a different active ingredient (gingerol from natural ginger extract) instead of synthetic 5-HT3 antagonists, altering the pharmacological profile to reduce adverse effects while maintaining antiemetic efficacy through a different mechanism of action
Solution Approach 2:
The invention uses a composite natural extract containing multiple gingerol compounds (6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol) in specific ratios, leveraging synergistic effects of multiple components to achieve both efficacy and safety
2Reliability
If 5-HT3 receptor antagonist antiemetics are administered, then vomiting is reduced, but delayed post-chemotherapy nausea develops and is not well-controlled
Solution Approach 1:
The patent administers gingerol extract before chemotherapy treatment to prevent the development of delayed post-chemotherapy nausea, acting in advance to block the nausea pathway before it can be triggered by chemotherapy
Solution Approach 2:
The invention provides continuous antiemetic coverage by administering gingerol extract at multiple time points (before and after chemotherapy), ensuring uninterrupted protection against both acute and delayed nausea phases
3Ease of operation
If pharmacologic agents are used to treat anticipatory nausea and vomiting, then symptom relief is sought, but no agents have achieved success
Solution Approach 1:
The patent administers gingerol extract before chemotherapy sessions to prevent anticipatory nausea and vomiting, addressing the psychological and physiological conditioning that occurs prior to treatment
Solution Approach 2:
The invention introduces gingerol as an intermediary substance that mediates between the chemotherapy trigger and the nausea response, blocking the conditioned reflex pathway through its action on the gastrointestinal system and central nervous system
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The ginger extract formulation significantly reduces nausea and vomiting in cancer patients, with reduced adverse events and improved efficacy for anticipatory and acute post-chemotherapy nausea, demonstrating a promising alternative to existing antiemetics.
Implementation Method 1
The methods feature supercritical, critical and near-critical fluids with and without polar cosolvents
Implementation Method 2
an extract of the ginger rhizome... formulated into a drug delivery system using supercritical, critical, or near-critical fluids
Data Source
AI summary
This invention is for an improved method for making enhanced ginger capsules and for using these capsules for treating nausea and emesis in cancer patients.