Gingival Crevice Carrier for Controlled Medicament Absorption
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Solution Overview
Problem
Existing methods for delivering medicaments, such as pills, patches, injections, and nasal sprays, have limitations including cost, pain, and restricted types of medicaments that can be delivered, while mucosal surfaces like the gingival crevice are challenging for efficient vaccine delivery due to high permeability and the need for strong mucosal immunity.
Innovation Solution
A junctional epithelial targeting (JET) device configured to deliver medicaments to the gingival crevice, either through controlled release via a carrier or by agitation, ensuring precise placement and absorption without gastrointestinal tract exposure, allowing for a wide range of medicaments including vaccines, vitamins, and antibiotics.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If conventional delivery methods (pills, patches, injections, nasal sprays) are used, then medicaments can be delivered to the body, but they have limitations including cost, pain, and restricted types of medicaments that can be delivered
Solution Approach 1:
The invention uses the gingival crevice as an intermediary delivery route between conventional methods and direct systemic absorption. This intermediary pathway allows diverse medicaments (vaccines, proteins, peptides, antibiotics, vitamins) to be delivered without gastrointestinal degradation, resolving the contradiction between ease of use and adaptability to different medicament types
Solution Approach 2:
The invention replaces mechanical injection systems with a non-invasive oral delivery system using the gingival crevice. This substitution eliminates pain associated with injections while maintaining effective medicament delivery, and replaces gastrointestinal absorption with direct gingival absorption, expanding the types of medicaments that can be effectively delivered
2Ease of manufacture
If vaccines are placed on top of mucosal surfaces, then delivery is simple, but mucosal surfaces are designed to keep material out thus not leading to efficient uptake
Solution Approach 1:
The invention exploits the unique local quality of the gingival crevice environment - specifically its high permeability and unique physiological conditions - to enable efficient medicament uptake. This localized approach transforms the general barrier property of mucosal surfaces into a targeted delivery advantage, resolving the contradiction between simple delivery and efficient uptake
3Reliability
If the JET device is inserted into the gingival crevice for medicament delivery, then non-invasive high bioavailability delivery is achieved, but precise placement and controlled release must be ensured
Solution Approach 1:
The device incorporates pre-formed carriers with controlled release properties that are prepared in advance with precise medicament loading. This preliminary preparation ensures controlled release kinetics and precise medicament placement upon device insertion, resolving the contradiction between high bioavailability and manufacturing precision
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The JET device provides non-invasive, high bioavailability, and easy-to-use medicament delivery, improving patient compliance and adherence to supplementation regimens by directly absorbing medicaments into the patient's system, bypassing the gastrointestinal tract.
Implementation Method 1
the carrier is configured to release a medicament in a controlled manner over a predetermined period of time. The rate of dissolution (and consequently, the rate of medicament release) may be configured to the specific therapeutic requirements by adjusting the composition and properties of the carrier material
Implementation Method 2
The high permeability of the JE, a characteristic not seen elsewhere within the mucosal system, offers easy passage to commensal bacteria, potential pathogens, and food allergens
Data Source
AI summary
A Junctional Epithelial Targeting (JET) device and a system for delivery of medicaments to the gingival crevice of a patient, and/or methods of manufacturing and/or using the JET device and system. The JET device comprises a carrier configured to carry and release medicaments within the gingival crevice over a controllable period of time, ensuring efficient absorption into the patient's system. The carrier is configured to dissolve in response to the moist environment of the gingival crevice, with the dissolution rate being adjustable based on the carrier's composition. A detachable handle facilitates the precise placement and subsequent detachment of the carrier within the gingival crevice. Additionally, a stop tab is incorporated to prevent over-insertion of the carrier. The JET device offers a non-invasive, rapid, and user-friendly approach to medicament delivery, potentially improving adherence to supplementation regimens, particularly for post-bariatric surgery patients and others at risk of micronutrient deficiencies.