Ginkgo Diterpene Lactone Composition for Depression
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Solution Overview
Problem
Current ginkgo diterpene lactone compositions do not fully leverage the synergistic effects of Ginkgolides A, B, C, J, and L to achieve optimal pharmacological activity for treating depression and oxidative stress.
Innovation Solution
A composition comprising 32-36 parts of Ginkgolide A, 55-58 parts of Ginkgolide B, 2.2-3.4 parts of Ginkgolide K, with additional Ginkgolides C, J, and L, totaling above 2.6 parts, which can be used in a ginkgo diterpene lactone preparation or injection, including pharmaceutically acceptable excipients, for antidepressant and cardiovascular applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If ginkgolide composition contains only GA, GB, and GK, then the composition is simpler to manufacture, but the pharmacological activity is insufficient
Solution Approach 1:
The patent combines multiple ginkgolide components (GA, GB, GK, GC, GJ, and GL) into a single composition. By merging these six different ginkgolide compounds with specific content ratios, the composition achieves synergistic pharmacological effects that enhance antidepressant and antioxidant activities while maintaining manufacturing feasibility through a unified formulation approach.
2Reliability
If the composition includes all six ginkgolides with optimal ratios, then the pharmacological activity is enhanced, but the composition complexity increases
Solution Approach 1:
The patent optimizes the composition by specifying precise content ratios for each ginkgolide component: GA at 30-40%, GB at 50-65%, GK at 0.5-5%, and GC, GJ, and GL each at 0.1-2%. By controlling these parameter ranges, the composition achieves enhanced pharmacological activity while managing complexity through standardized formulation parameters that can be consistently reproduced in manufacturing.
Data Source
AI summary
The present invention relates to a ginkgo diterpene lactone composition. The composition has the effect of improving a depressive state; the composition can prolong a tail flick interval time and a swimming interval time of a mouse to different degrees and can also increase the frequency of escaping from electric shock to different degrees; moreover, the additional addition of a certain amount of ginkgolide C, ginkgolide J, and ginkgolide L greatly enhances the effect of improving the depressive state. Furthermore, in the present invention, it is further proved through experiments that after the provision of the ginkgo diterpene lactone composition, indexes, such as SOD, MDA, GSH, and TAC, can be improved to different degrees, for example, after the addition of a certain amount of ginkgolide C, ginkgolide J, and ginkgolide L, the improving effect gets more obvious, the oxidative stress level can be better improved, and the oxidative damage can be relieved.