Ginseng Berry Extract Suppresses Vascular Inflammation
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Solution Overview
Problem
Current cardiovascular drugs for treating arteriosclerosis, such as ACE inhibitors and HMG-CoA reductase inhibitors, are expensive and lead to adverse effects with long-term use, and existing treatments fail to effectively suppress vascular inflammation factors like TNF-α and NO generation.
Innovation Solution
A composition using an extract of ginseng berry (Panax ginseng C.A. Meyer) as an active ingredient, which is different in content and composition from ginseng root, to suppress aortic atheromatous plaques and reduce TNF-α and NO generation, thereby preventing or treating arteriosclerosis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cardiovascular drugs (ACE inhibitors, HMG-CoA reductase inhibitors) are used to treat arteriosclerosis, then therapeutic effect is achieved, but long-term medication leads to adverse effects and high cost
Solution Approach 1:
The patent employs ginseng berry extract, a natural herbal substance, as a temporary and cost-effective alternative to long-term synthetic medication. The extract provides therapeutic effects without the adverse effects associated with prolonged use of conventional drugs, acting as a natural remedy that can be used without the same level of concern for long-term safety issues.
Solution Approach 2:
The patent shifts from synthetic chemical compounds to natural ginseng berry extract, changing the fundamental parameter of the active ingredient. This parameter change from artificial to natural substances fundamentally alters the safety profile, eliminating the adverse effects while maintaining therapeutic effectiveness for arteriosclerosis treatment.
2Duration of action of stationary object
If conventional cardiovascular drugs are used for long-term treatment, then arteriosclerosis is managed, but medication cost increases and adverse effects accumulate
Solution Approach 1:
The ginseng berry extract serves as an economical alternative to expensive synthetic medications. By using a natural extract that can be obtained at lower cost, the patent provides a cost-effective solution for long-term arteriosclerosis management, reducing the financial burden on patients while maintaining continuous therapeutic effects.
3Reliability
If conventional drugs are used to suppress vascular inflammation, then some therapeutic effect is achieved, but they fail to effectively suppress vascular inflammation factors like TNF-α and NO generation
Solution Approach 1:
The patent extracts and utilizes specific active components from ginseng berry that have direct anti-inflammatory properties. By taking out the beneficial components from the ginseng berry matrix, the extract provides targeted suppression of vascular inflammation factors such as TNF-α and NO generation, achieving more effective inflammation control than conventional drugs.
Solution Approach 2:
The patent changes the chemical composition parameter by using ginseng berry extract instead of synthetic drugs. This parameter change enables more effective suppression of vascular inflammation factors, as the natural extract contains compounds that directly target and reduce TNF-α and NO generation, providing superior anti-inflammatory activity.
Data Source
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AI summary
A composition according to the present invention is a composition containing extract of Panax ginseng C.A. Meyer fruit as an active ingredient for preventing or treating artherosclerosis. The extract is confirmed to effectively suppress lesions or generation of a vascular inflammation factor caused by artherosclerosis. Thus, the composition is suitable for use as an active ingredient of the composition for preventing or treating artherosclerosis.