Ginseng Composition Rare Ginsenosides Bioavailability

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Solution Overview

Problem

The bioavailability of ginsenosides from traditional Panax ginseng is limited, leading to inadequate therapeutic effects due to extensive pre-systemic metabolism and low absorption rates, which hampers their effectiveness in improving cognitive performance and treating stress and skin conditions.

Innovation Solution

A composition comprising a rare ginsenoside, ginsan, and gintonin, formulated at specific ratios, is used to enhance bioavailability and adaptogenic effects, improving cognitive performance, reducing stress, and treating skin conditions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If traditional Panax ginseng constituents are administered orally, then the composition is easy to administer, but the bioavailability is limited due to extensive pre-systemic metabolism and low absorption rates

Engineering Contradiction:

Improveease of administrationVSAvoidbioavailability

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent changes the chemical parameters of ginseng constituents by using rare ginsenosides (Rg6, Rh4, Rg3, PPT, Rk1, Gd, Rg5, Rh2, Rh3, PPD) instead of traditional ginsenosides, and controls their concentration ratios (rare ginsenosides 1-50%, ginsan 50-80%, gintonin 50-80%) to achieve improved bioavailability and therapeutic effects while maintaining oral administration

Inventive Principle:

Principle #35Parameter changes

2Device complexity

If traditional ginseng constituents are used, then the composition is simple to formulate, but the therapeutic effects are non-significant or difficult to interpret

Engineering Contradiction:

Improvecomposition complexityVSAvoidtherapeutic effectiveness

Core Design Contradiction:

Device complexityVSReliability

Solution Approach 1:

The patent creates a composite composition containing three types of ginseng constituents (rare ginsenosides, ginsan polysaccharides, and gintonin glycolipoproteins) with specific ratio ranges, where each component contributes different therapeutic properties that work synergistically to improve cognitive performance, reduce stress, and treat skin conditions

Inventive Principle:

Principle #40Composite materials

3Reliability

If orally administered doses of ginsenosides are increased to achieve therapeutic brain concentrations, then the therapeutic effect may be improved, but the pre-systemic metabolism and loss of substance increases

Engineering Contradiction:

Improvetherapeutic effectVSAvoidpre-systemic metabolism

Core Design Contradiction:

ReliabilityVSLoss of substance

Solution Approach 1:

The patent changes the chemical structure parameters by selecting rare ginsenosides with different metabolic stability profiles compared to traditional ginsenosides, and optimizes their concentration ratios to achieve sufficient brain tissue levels while minimizing pre-systemic metabolism and improving overall substance utilization

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentEP4025231B1Ginseng composition and use thereof as a medicament

Publication Date: 2024.08.28 BOTALYS SA

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AI summary

The invention pertains to a composition, a kit and preparation thereof. The invention also pertains to the composition for use as a medical or therapeutic substance. The composition comprises a rare ginsenoside, a ginsan and a gintonin. Preferably, the ratio of ginsan to gintonin is at least 500:1 and at most 1:100. Preferably, the ratio of rare ginsenosides to ginsan and gintonin is at least 250:1 and at most 1:40.