Glancing Angle Grating Interferometer for High-Energy X-Ray Phase Contrast

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Solution Overview

Problem

Conventional X-ray differential phase contrast (DPC) imaging methods face challenges in achieving efficient phase contrast imaging with high energy X-rays due to difficulties in fabricating micron-period absorption gratings required for higher energy X-rays, limiting contrast and practical applications, especially in medical and industrial settings.

Innovation Solution

A method using a multi-sector source grating, beam-splitter grating, and analyzer grating interferometer, where the object is positioned between the beam-splitter and analyzer gratings, allowing for multiple image acquisition during a single exposure with varying interferometer phasing, and combining these images to produce a phase contrast image, enabling efficient phase contrast imaging over a broad energy range, including high energy X-rays.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional absorption gratings are used for high energy X-rays, then phase contrast imaging can be achieved, but the grating fabrication becomes extremely difficult and contrast is limited

Engineering Contradiction:
Improvephase contrast imaging qualityVSAvoidgrating fabrication difficulty
Core Design Contradiction:
Measurement precisionVSEase of manufacture

Solution Approach 1:

The patent changes the fundamental parameter of grating operation from normal incidence to glancing angle incidence. This parameter change allows the use of much thinner grating structures (overcoming fabrication difficulties) while maintaining effective phase contrast imaging at high X-ray energies through the enhanced path length interaction at glancing angles.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs composite grating structures combining absorbing materials (such as gold or tungsten) with supporting substrate materials. This composite approach enables the creation of thin, fragile absorbing elements that can be fabricated at glancing angles without requiring deep, complex groove structures, thus resolving the fabrication difficulty while maintaining imaging quality.

Inventive Principle:
Principle #40Composite materials

2Adaptability or versatility

If normal incidence grating interferometers are used, then phase contrast imaging is achievable, but the system is limited to lower X-ray energies due to fabrication constraints

Engineering Contradiction:
Improveenergy range coverageVSAvoidgrating fabrication feasibility
Core Design Contradiction:
Adaptability or versatilityVSEase of manufacture

Solution Approach 1:

The patent changes the incidence angle parameter from normal to glancing angle, which fundamentally alters the interaction between X-rays and the grating structure. This enables the system to operate effectively across a broad energy range including high energies, as the glancing angle geometry reduces the required grating thickness and relaxes fabrication constraints.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent introduces a new dimensional approach by tilting the grating planes to glancing angles relative to the X-ray beam. This dimensional change in the grating orientation enables high energy X-ray phase contrast imaging without requiring the deep, complex structures that would be needed at normal incidence, thus expanding energy range coverage.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

3Measurement precision

If multiple sequential exposures are used for phase stepping, then phase contrast information can be extracted, but imaging time increases and productivity decreases

Engineering Contradiction:
Improvephase contrast information accuracyVSAvoidimaging speed
Core Design Contradiction:
Measurement precisionVSProductivity

Solution Approach 1:

The patent employs periodic modulation of the grating positions to create phase-stepped interference patterns. By using multiple gratings with different fixed phase offsets (rather than sequential stepping), the system captures phase information simultaneously in a single exposure, maintaining measurement precision while dramatically improving imaging speed and productivity.

Inventive Principle:
Principle #19Periodic action

Solution Approach 2:

The patent pre-configures multiple gratings with different phase offsets before the exposure is made. This preliminary arrangement of gratings allows all phase steps to be captured simultaneously in one exposure, eliminating the need for sequential stepping during the exposure and thus maintaining accurate phase contrast measurement while improving imaging throughput.

Inventive Principle:
Principle #10Preliminary action

4Use of energy by moving object

If crystal optics are used for DPC imaging, then high intensity X-rays can be utilized, but the system is limited to synchrotron sources and cannot work with conventional X-ray tubes

Engineering Contradiction:
ImproveX-ray intensity utilizationVSAvoidsource compatibility
Core Design Contradiction:
Use of energy by moving objectVSAdaptability or versatility

Solution Approach 1:

The patent changes the optical interaction parameter from the extreme precision required by crystal diffraction to the more tolerant grating-based phase modulation at glancing angles. This parameter change allows the system to work with conventional X-ray tube sources that have lower intensity and broader spectral width, greatly expanding source compatibility while still utilizing X-ray energy effectively.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent replaces expensive, complex crystal optics with simpler, more robust grating structures that can be fabricated using standard microfabrication techniques. This substitution enables the use of conventional, inexpensive X-ray tube sources instead of requiring expensive synchrotron facilities, making the system adaptable to a wide range of source types including portable and clinical X-ray systems.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for high-resolution, clinically compatible dose, and scanning speed phase contrast imaging of large objects, enhancing soft tissue contrast and spatial resolution, suitable for medical and industrial applications, and overcoming the limitations of conventional grating shearing methods at higher energies.

Implementation Method 1

X-ray differential phase-contrast (DPC) imaging relies on the refraction of the X-rays passing through an object

Methodology Applied
Scientific EffectRefraction: Refraction

Implementation Method 2

the basic technique used for DPC imaging is to angularly filter with μ-radian resolution the transmitted X-ray beam, thus converting the angular beam deviations from refraction into intensity changes

Methodology Applied
Scientific EffectInterference: Interference

Data Source

PatentEP3139836B1System and method for phase-contrast x-ray imaging
Publication Date: 2021.07.07 JOHNS HOPKINS UNIVERSITY
  • EP3139836B1 patent drawingFigure 1A~1B
  • EP3139836B1 patent drawingFigure 2A~2B
  • EP3139836B1 patent drawingFigure 3A~3B

AI summary

A differential phase contrast X-ray Imaging system includes an X-ray illumination system, a beam splitter arranged in a radiation path of the X-ray illumination system, and a detection system arranged in a radiation path to detect X- rays after passing through the beam splitter.