Glass-Ceramic Bone Graft Composite With Strength and Degradability
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Solution Overview
Problem
Existing artificial bone materials face challenges in providing sufficient mechanical strength, biocompatibility, and osteoconductivity, as well as inadequate degradability for effective bone regeneration and integration with human tissue.
Innovation Solution
A glass-ceramic composite material comprising CaO—MgO—SiO2 glass and CaMgSi2O6 ceramic phases, combined with CaSO4 ceramic, which offers high mechanical strength, biocompatibility, and osteoconductivity, with CaSO4 promoting rapid degradation for bone ingrowth.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If bioactive glass is used as bone graft material, then ability to connect to bone and soft tissue is improved, but degradability is insufficient
Solution Approach 1:
The patent combines bioactive glass (CaO-MgO-SiO2 system) with calcium sulfate and collagen to create a composite bone graft material. The bioactive glass provides bone connection ability through dissociated ions (Si4+, Ca2+, Na+, P5+), while calcium sulfate contributes rapid degradability and collagen provides structural framework, together resolving the contradiction between bone connection ability and degradability
2Ease of manufacture
If synthetic bone materials are used, then production cost and large-scale production capability are improved, but mechanical strength and osteoconductivity are insufficient
Solution Approach 1:
The patent creates a composite material combining synthetic bioactive glass (easy to manufacture) with calcium sulfate and collagen (provide mechanical strength and osteoconductivity). The synergistic combination allows large-scale production while achieving sufficient mechanical properties and bone regeneration capability
3Ease of manufacture
If existing artificial bone materials are used, then ease of production is improved, but ability to promote bone cell differentiation and integration is insufficient
Solution Approach 1:
The patent combines synthetic bioactive glass (easy production) with calcium sulfate (promotes bone ingrowth) and collagen (provides osteoconductivity and structural support). This composite structure maintains production ease while significantly enhancing bone cell differentiation and integration capabilities through the synergistic effects of all components
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composite material achieves enhanced biocompatibility, rapid degradation for bone integration, and high mechanical strength, supporting effective bone regeneration and tissue integration.
Implementation Method 1
the components (Si4+, Ca2+, Na+, P5+) dissociated from which in the simulated body fluid stimulate the formation of new bone
Implementation Method 2
In the glass melting step, the temperature is set at 1500° C. and maintained for 2 hours
Implementation Method 3
a glass-ceramic composite material mainly comprising CaO—MgO—SiO2 in glass phase, CaMgSi2O6 in crystalline phase and CaSO4 in crystalline phase
Data Source
AI summary
The present invention relates to a glass-ceramic composite material, which is a composite material with degradability and osteoconductivity, and is composed of CaO—MgO—SiO2 (CMS glass)+CaMgSi2O6 (CMS ceramic) and CaSO4 (CS ceramic). In addition to the CaO—MgO—SiO2 glass, this synthesized composite material mainly includes two ceramics of CaMgSi2O6 and CaSO4 in crystalline phase, wherein, both the CMS glass and CMS ceramic have high mechanical strength, biocompatibility and osteoconductivity, while CaSO4 has the characteristics of rapid degradation to promote bone ingrowth.