Inorganic Nanoparticle Production via Glass Degradation

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Solution Overview

Problem

Current methods for producing inorganic nanomaterials are limited in versatility and cost-effectiveness for applications such as tissue repair, biomedical imaging, and electronics, as they rely on expensive salts and complex processes.

Innovation Solution

A method involving mixing glass raw materials with nanoparticle base materials to form a parent glass mixture, heating, cooling, and degrading the glass to release nanoparticles, which can include borate or borosilicate glasses doped with metal ions or oxides, allowing for controlled nanoparticle formation and release.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If soluble salts and complex chemical processes are used to produce inorganic nanomaterials, then nanoparticle formation is achieved, but production cost increases and process complexity increases

Engineering Contradiction:
Improvenanoparticle formation controlVSAvoidprocess complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent changes the chemical state parameters of the glass material through controlled heating and cooling cycles. The glass is heated to melt and then cooled at specific rates to control nanoparticle formation, transforming the material from amorphous to nanocrystalline state without complex chemical additives

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention utilizes phase transitions of glass material during heating and cooling to induce nanoparticle formation. The glass undergoes melting followed by controlled cooling that triggers crystallization of nanoparticles within the glass matrix, eliminating the need for complex precipitation or reduction processes

Inventive Principle:
Principle #36Phase transitions

2Manufacturing precision

If soluble salts and complex chemical processes are used to produce inorganic nanomaterials, then nanoparticle formation is achieved, but production cost increases

Engineering Contradiction:
Improvenanoparticle formation controlVSAvoidproduction cost
Core Design Contradiction:
Manufacturing precisionVSEase of manufacture

Solution Approach 1:

The patent replaces expensive soluble salts with inexpensive glass raw materials as the source of nanomaterial precursors. The glass material serves as a disposable matrix that can be readily transformed into nanoparticles through thermal processing, significantly reducing material costs

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The invention replaces complex chemical processes with thermal processing mechanisms. Instead of using chemical precipitation or reduction reactions, the patent uses controlled heating and cooling to induce phase transitions and nanoparticle formation, simplifying the manufacturing process

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Adaptability or versatility

If glass material is used to form nanoparticles through degradation, then cost-effectiveness improves and versatility increases, but control over nanoparticle release timing becomes challenging

Engineering Contradiction:
Improvenanoparticle composition varietyVSAvoidrelease timing control
Core Design Contradiction:
Adaptability or versatilityVSManufacturing precision

Solution Approach 1:

The patent performs preliminary action by forming nanoparticles within the glass matrix during the manufacturing process itself. The glass is heated and cooled to pre-form nanoparticles before the final product is used, allowing control over nanoparticle characteristics while maintaining the ability to release them through subsequent glass degradation

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The invention introduces dynamics by allowing the glass matrix to degrade over time or under specific conditions, releasing pre-formed nanoparticles in a controlled manner. The system transitions from a static glass-nanoparticle composite to a dynamic release system that can respond to environmental conditions

Inventive Principle:
Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method is cost-effective, adaptable for various nanoparticle compositions and sizes, and enables controlled release of nanoparticles for medical and electronic applications, with potential for indefinite shelf life and controlled delivery.

Implementation Method 1

cooling the parent glass melt to a second temperature to solidify the parent glass melt, forming a parent glass

Methodology Applied
Scientific EffectCooling: Cooling

Implementation Method 2

reacting or degrading the parent glass by contact with a solvent or fluid, wherein the nanoparticles are created as the parent glass reacts or degrades

Methodology Applied
Scientific EffectChemical reaction: Chemical Bonding

Data Source

PatentUS10350330B2Method to produce inorganic nanomaterials and compositions thereof
Publication Date: 2019.07.16 THE CURATORS OF THE UNIVERSITY OF MISSOURI
  • US10350330B2 patent drawing
  • US10350330B2 patent drawing
  • US10350330B2 patent drawing

AI summary

A solid state method of producing inorganic nanoparticles using glass is disclosed. The nanoparticles may not be formed until the glass is reacted with or degraded by contact with a fluid in vivo or in vitro.