Ganoderma lucidum Polysaccharide GLP-3 Chemotherapy Toxicity Reduction
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for advanced cancer, particularly in patients who are no longer surgical candidates and have a limited life expectancy, struggle to effectively reduce tumor size, alleviate toxic side effects of chemotherapy, and improve patient appetite and quality of life.
Innovation Solution
A method for extracting Ganoderma lucidum polysaccharide GLP-3 with a defined molecular structure, which involves dusting and drying Ganoderma lucidum, crushing it into powder, dissolving it in water under high temperature and pressure, using membrane concentration technology, and purifying through column chromatography and lyophilization.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If chemotherapy drugs are used to treat advanced cancer, then tumor size is reduced, but toxic side effects on the human body increase
Solution Approach 1:
The patent introduces Ganoderma lucidum polysaccharide GLP-3 as an intermediary substance that combines with chemotherapy drugs to enhance antitumor efficacy while reducing toxic side effects. The polysaccharide acts as a mediator between the chemotherapy drug and the tumor, allowing the drug to target cancer cells more effectively while protecting normal cells from damage.
Solution Approach 2:
The patent creates a composite treatment system by combining Ganoderma lucidum polysaccharide GLP-3 with chemotherapy drugs. This composite approach integrates the antitumor properties of the polysaccharide with the cytotoxic effects of the chemotherapy drug, achieving synergistic therapy that reduces tumor size while minimizing harmful side effects.
2Ease of manufacture
If conventional extraction methods are used to obtain polysaccharides, then production cost is reduced, but manufacturing precision and purity are insufficient
Solution Approach 1:
The patent divides the extraction process into distinct sequential steps: crude extraction, membrane filtration, column chromatography, and lyophilization. Each step segments the purification process to remove specific impurities at different stages, achieving high purity through multiple separation operations while maintaining cost-effectiveness.
Solution Approach 2:
The patent replaces conventional mechanical extraction methods with a combination of membrane filtration technology and column chromatography. These advanced separation techniques provide superior purity without requiring complex or expensive equipment, achieving high manufacturing precision through sophisticated but accessible purification methods.
3Productivity
If polysaccharide extraction requires high temperature and pressure, then extraction efficiency is improved, but energy consumption increases
Solution Approach 1:
The patent optimizes the extraction parameters by using controlled high temperature (100-200°C) and pressure conditions specifically for the initial dissolution step, then transitioning to lower temperature purification steps. This parameter change strategy achieves high extraction efficiency for polysaccharide solubility while managing overall energy consumption through targeted thermal application.
Solution Approach 2:
The patent utilizes phase transition processes, including the dissolution of polysaccharides at elevated temperatures and the subsequent lyophilization (freeze-drying) process. These phase changes enable efficient extraction and concentration of the polysaccharide while managing energy requirements through controlled thermal and pressure transitions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The extracted Ganoderma lucidum polysaccharide GLP-3 demonstrates antitumor efficacy, reduces tumor size, alleviates toxic side effects of chemotherapy, and improves patient appetite and quality of life, while also preventing mutations in normal human cells and cancer cell formation.
Implementation Method 1
using membrane concentration technology to separate the medicinal juice solution to obtain a concentrated solution with an active ingredient
Implementation Method 2
followed by multiple column chromatography separations as well as concentration and lyophilization to obtain the Ganoderma lucidum polysaccharide GLP-3
Implementation Method 3
followed by multiple column chromatography separations as well as concentration and lyophilization to obtain the Ganoderma lucidum polysaccharide GLP-3
Data Source
AI summary
This invention pertains to the field of plant extraction and separation technology, and provides a polysaccharide compound with a defined molecular structure that possesses antitumor efficacy and mitigates the toxic side effects of chemotherapy. The polysaccharide compound is intended for the treatment of advanced cancer patients (those who are no longer candidates for surgery, have a life expectancy of only three to six months, and are still eligible for chemotherapy). The molecular formula of the polysaccharide compound is: (C66H110O55)n. The active ingredient, polysaccharide, is obtained through the extraction of effective components from Ganoderma lucidum under high temperature and high pressure. The polysaccharide with this active ingredient, characterized by its water solubility, is readily absorbed by the human body, offers antitumor effects, and has proven efficacy in the prevention of tumor development in humans.