Glu-Hyp-Gly Peptide Composition for Direct Brain Cell Differentiation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing collagen-derived peptides do not effectively promote brain function improvement or prevent decline by directly acting on cerebral nerve cells, and their specific actions are unclear.
Innovation Solution
A brain function regulating agent comprising a peptide with an amino acid sequence of Glu-Hyp-Gly, its salts, or chemically modified products, which promotes cerebral nerve cell differentiation and prevents decline by directly acting on cerebral nerve cells.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If collagen peptide mixtures are administered to improve brain function, then brain function improving effect is observed, but the specific active peptides and their direct action on cerebral nerve cells remain unidentified
Solution Approach 1:
The patent segments the collagen peptide mixture into individual peptide components and evaluates each one's specific effect on cerebral nerve cells. This allows identification of the active peptide (Glu-Hyp-Gly) responsible for the brain function improving effect, resolving the contradiction between observing overall effect and identifying specific active components.
Solution Approach 2:
The patent extracts and isolates specific collagen-derived peptides from the mixture to test their individual effects. By taking out specific peptides like Glu-Hyp-Gly for targeted evaluation, the invention identifies which specific component produces the neurogenesis-promoting action, thereby resolving the information loss about active ingredients.
2Reliability
If existing collagen-derived peptides are used, then some physiological activities are exhibited, but direct action on cerebral nerve cells without signal transducers is not confirmed
Solution Approach 1:
The patent uses Glu-Hyp-Gly as a specific intermediary substance to mediate the effect between collagen administration and cerebral nerve cell differentiation. The study confirms this peptide directly acts on cerebral nerve cells to promote differentiation, providing the missing mechanistic information while maintaining the reliable physiological activity observation.
3Reliability
If collagen peptide mixtures are administered, then neurogenesis promoting action is observed, but the specific peptide sequence responsible is not specified
Solution Approach 1:
The patent segments the collagen peptide mixture into individual peptides with specific amino acid sequences. By evaluating each segmented peptide's effect on neurogenesis, the invention identifies Glu-Hyp-Gly as the specific sequence responsible for the neurogenesis-promoting action, thereby achieving both reliable effect observation and precise sequence specification.
Solution Approach 2:
The patent applies local quality analysis by examining specific peptide sequences within the mixture. It identifies that the local structure of Glu-Hyp-Gly (specific amino acid sequence) is what confers the neurogenesis-promoting property, allowing precise specification of the active peptide sequence while maintaining the observed biological effect.
Data Source
AI summary
A brain function regulating agent contains a peptide comprising an amino acid sequence represented by Glu-Hyp-Gly, a salt thereof, or a chemically modified product thereof.