Aldehyde-Modified Glucan Adhesive for Controlled Tissue Decomposition
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Solution Overview
Problem
Current medical adhesives for surgical applications, such as cyanoacrylate and fibrin glue, face issues with flexibility, decomposition, and viral infection concerns, while alternative polymers like aldehyde dextran-polymer chitosan and micelle-forming terminal aldehyde polymers have limitations in adhesive strength and stability.
Innovation Solution
A two-component reactive adhesive system comprising aldehyde-modified glucan and partially carboxylated poly-L-lysine, with a specific aldehyde-to-amino group ratio, is developed, allowing for adjustable disintegration time and high adhesive strength, using a powder spray device for precise application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If cyanoacrylate adhesive is used, then adhesion strength is improved, but flexibility deteriorates and decomposition resistance worsens
Solution Approach 1:
The patent changes the chemical parameters of the adhesive by using aldehyde-modified glucan (with controlled molecular weight 1,000-200,000) and partially carboxylated poly-L-lysine (with residual amino group ratio 70-93%) instead of conventional cyanoacrylate. This parameter change enables the adhesive to achieve both strong adhesion and flexibility, while allowing controlled decomposition in the body.
Solution Approach 2:
The patent creates a composite adhesive system combining aldehyde-modified glucan and partially carboxylated poly-L-lysine that react to form a hydrogel. This composite material structure provides both high adhesion strength and flexibility, resolving the contradiction between these properties in conventional single-material adhesives.
2Reliability
If fibrin glue is used, then biocompatibility is improved, but adhesive strength deteriorates
Solution Approach 1:
The patent changes the adhesive components from fibrin-based to aldehyde-modified glucan and partially carboxylated poly-L-lysine with specific parameters (molecular weight ranges, residual amino group ratios). This enables achieving both high adhesive strength and good biocompatibility, as the materials are designed to be non-thrombogenic and compatible with living tissues while providing strong bonding.
3Strength
If polymer chitosan is used, then adhesion is improved, but decomposition control deteriorates
Solution Approach 1:
The patent uses aldehyde-modified glucan with controlled molecular weight (1,000-200,000) and aldehyde group content (0.2-0.5 per anhydroglucose unit) to control the disintegration time. By adjusting these parameters, the adhesive can be designed to disintegrate after a specific period (e.g., 1-4 weeks), providing precise control over the duration of action while maintaining strong initial adhesion.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system provides strong adhesion, flexibility, and controlled self-decomposition, ensuring reliable tissue adherence and easy removal, with improved storage stability and reduced toxicity.
Implementation Method 1
a first reactant comprising a powder of aldehyde-modified glucan... and a second reactant comprising a powder of partially carboxylated poly-L-lysine... the first and second reactants are mixed with each other so that aldehyde-to-amino group ratio becomes in a range of 0.9 to 2.0
Implementation Method 2
the first and second reaction component are reacted with each other in the presence of water... hardened into a gel
Implementation Method 3
The medical adhesive is decomposed, fluidized and excreted after a certain period of time after the reaction components are allowed to react with each other and hardened into a gel
Implementation Method 4
by which various powders, such as powders with low bulk density and low fluidity, can be continuously and as uniformly discharged as possible by compressed air or pressurized gas
Data Source
AI summary
A powder spray device includes a funnel member, a first three-way joint, an air-current supply tube, a discharge tube, a vibration motor, a bypass air-current tube, and a switching mechanism. The first three-way joint has a first opening connected to an outlet at a lower end of the funnel member. The air-current supply tube and discharge tube are respectively connected to second and third openings of the first three-way joint. The vibration motor is fixed onto an outer surface of a funnel body of the funnel member. The bypass air-current tube branches off from the air-current supply tube and is connected to the discharge tube. The switching mechanism switches from and to standby state, in which compressed gas is sent only through the bypass air-current tube, to and from spray-coating state, in which compressed gas is sent out through the air-current supply tube, and also through the bypass air-current tube.