Glucan Shell-Core Carrier for Nutrient Stability
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Natural active components in functional foods face challenges such as high melting points, poor water solubility, easy photolysis, and oxidative decomposition, leading to low bioavailability and gastrointestinal instability in drug carriers, which affects their effectiveness in preventing chronic diseases.
Innovation Solution
A glucan-based shell-core structure carrier material is developed using soluble starch particles modified by glycosyltransferase to form a crystalline outer shell and amorphous inner core, enabling improved bioavailability and stability of functional nutritional components through a vine winding method.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If natural active components are used directly in functional foods, then the functional effects are provided, but the bioavailability is low due to poor water solubility, easy photolysis, and oxidative decomposition
Solution Approach 1:
The patent embeds natural active components inside the glucan-based shell-core structure carrier, creating a nested configuration where the core contains the active ingredient and the shell provides protection. This nesting approach protects the active component from environmental factors (photolysis, oxidation) while maintaining controlled release for improved bioavailability
Solution Approach 2:
The patent creates a composite carrier system combining glucan-based materials with specific shell-core structure to encapsulate and deliver natural active components. The composite structure integrates the protective properties of glucan with the functional properties of the encapsulated active ingredient, resolving the contradiction between stability and bioavailability
2Adaptability or versatility
If protein biomacromolecules are used as drug carriers, then the carrying function is provided, but the gastrointestinal stability is poor and absorption is difficult
Solution Approach 1:
The patent changes the material parameter from protein biomacromolecules to glucan-based materials, which have superior gastrointestinal stability. The glucan-based shell-core structure maintains the carrying function while improving stability in the gastrointestinal environment, allowing for better absorption and reduced degradation
3Quantity of substance
If starch-based carrying materials are used, then the water solubility is improved, but the manufacturing process becomes complicated and yield is lower
Solution Approach 1:
The patent segments the starch-based material into spherical hyperbranched structures with controlled molecular weight and particle size. This segmentation simplifies the manufacturing process by creating uniform, predictable structures that are easier to produce at scale while maintaining water solubility and carrying capacity
Solution Approach 2:
The patent creates local quality differences within the carrier structure by forming a shell-core configuration where the shell and core have different properties. The shell provides protection and controlled release, while the core contains the active ingredient, optimizing both manufacturability and functional performance
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The glucan-based shell-core structure carrier material enhances the biological stability and slow-release effect of functional active components, offering a simple production process with high yield and safety, while effectively protecting and regulating their delivery and release.
Implementation Method 1
performing grafting and chain extending on glucosyl groups on the outer surfaces of spherical hyperbranched water-soluble starch particles by α-1,4 glycosidic bonds by using glycosyltransferase
Implementation Method 2
The glucan-based shell-core structure carrier material can improve the biological stability, biological utilization effectiveness and slow-release effect of functional active components
Data Source
AI summary
The present invention discloses a glucan-based shell-core structure carrier material and preparation and application thereof, and belongs to the technical field of modern food processing. Spherical hyperbranched water-soluble amylum grains are used as the raw material, and an enzymatic grafting and chain extending process is adopted for treatment to modify the surfaces of water-soluble glucan molecules into a firm shell structure with densely cumulated crystal structures, and form the glucan-based carrying material with the shell-core structure of which an inner core cavity has an amorphous state and an outer shell layer has a crystalline state. The adopted spherical hyperbranched water-soluble amylum grains have wide sources of raw materials and are not limited by producing areas and seasons; the preparation has simple and convenient steps, easy operation, controllable reaction conditions, relatively low cost and basically no pollution to the environment; and the prepared product can effectively protect, deliver and release functional nutritional components, can be applied to multiple fields of food, medicine, chemicals for daily use and the like, and has great market prospects and broad economic benefits.