Noninvasive Glucose Analyzer Using Skin Tissue Modulation
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Solution Overview
Problem
There is a need for a noninvasive method to determine glucose concentration in the human body effectively, as existing technologies face challenges in accurately measuring glucose levels without invasive procedures.
Innovation Solution
A noninvasive glucose concentration analyzer system that uses an applied force-optic analyzer to modulate skin tissue layers, applying physical forces to alter optical pathways and detect glucose concentrations through spectrometry, allowing for noninvasive analysis of glucose levels in the dermis layer without penetrating the subcutaneous fat layer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If noninvasive optical analysis is used to measure glucose concentration, then patient comfort and safety are improved, but measurement precision deteriorates due to interference from overlying tissue layers
Solution Approach 1:
The patent segments the tissue structure into distinct layers (epidermis, dermis, subcutaneous fat) and selectively targets the dermis layer for glucose measurement. By using multiple illumination zone-to-detection zone distances, the system isolates optical pathways that predominantly sample the dermis, excluding interference from the epidermis and subcutaneous fat layers.
Solution Approach 2:
The patent introduces a depth dimension to the optical measurement by controlling illumination zone-to-detection zone distances. This enables selective sampling of specific tissue depths, allowing the system to focus on the dermis layer where glucose concentration is most representative while avoiding contamination from other layers.
2Measurement precision
If multiple illumination zone-to-detection zone distances are used to target common tissue depth, then measurement precision is improved, but device complexity increases
Solution Approach 1:
The patent employs a single detector that serves multiple functions by receiving optical energy from multiple illumination zones at different distances. This universal detector design eliminates the need for multiple detectors or complex switching mechanisms, reducing device complexity while maintaining the ability to sample at different depths.
Solution Approach 2:
The patent combines multiple optical pathways with different illumination zone-to-detection zone distances into a single detection system. By merging these pathways and using a common detector, the system achieves depth-resolved measurements without requiring separate detection channels for each distance.
3Object-affected harmful factors
If optical energy detection is used to determine glucose concentration, then noninvasive measurement is achieved, but measurement precision deteriorates due to variable tissue properties
Solution Approach 1:
The patent changes the geometric parameter of illumination zone-to-detection zone distance to control the depth of optical penetration. By adjusting this distance, the system optimizes the sampling depth to target the dermis layer, compensating for variations in tissue properties and maintaining consistent measurement conditions across different patients and measurement sites.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enables accurate and noninvasive measurement of glucose concentrations by modulating skin tissue layers to enhance optical pathway analysis, providing reliable glucose monitoring without the need for invasive procedures.
Implementation Method 1
applying physical forces to alter optical pathways and detect glucose concentrations through spectrometry
Implementation Method 2
detect glucose concentrations through spectrometry
Data Source
AI summary
The invention comprises a method and apparatus for sampling optical pathways having a common tissue depth, such as a maximum mean depth of penetration in the dermis, with a common sample position of a person for analysis in a noninvasive analyte property determination system, comprising the steps of: probing skin with a range of illumination zone-to-detection zone distances with at least two wavelength ranges and detecting, using a set of detectors, illumination zone-to-detection zone distances having mean optical pathways probing the common tissue layer, such as without the mean optical pathways entering the subcutaneous fat layer of the person. Optionally, the skin tissue layers are modulated and/or treated via tissue displacement before and/or during data collection. Optionally, given illumination zone-to-detection zone distances are dynamically selected based upon a measure of state of the skin of the person.