Blood Glucose Calibration Triggered by Estimated Level Changes
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current non-invasive blood glucose measurement systems require frequent calibration using invasive methods, leading to unnecessary painful blood sample collections, even when there are minimal changes in blood glucose levels, due to the lack of determining if the invasive measurement data is sufficient for calibration.
Innovation Solution
A blood glucose measurement system that includes an invasive and non-invasive apparatus, where the invasive apparatus collects blood samples only when necessary based on changes in estimated glucose levels, using a controller to manage actuation signals and calibration data to reduce the frequency of invasive measurements and display estimated glucose levels during calibration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If blood glucose level is measured periodically with invasive apparatus, then calibration accuracy is maintained, but number of painful blood sample collections increases
Solution Approach 1:
The system continuously monitors the estimated blood glucose level and compares it with the calibration target value. When the difference exceeds a predetermined threshold, it automatically triggers an invasive measurement to update calibration data. This feedback mechanism ensures calibration accuracy is maintained only when necessary, reducing unnecessary painful blood sample collections.
Solution Approach 2:
The system dynamically adjusts the calibration process based on real-time changes in estimated blood glucose levels. Instead of fixed periodic measurements, the calibration trigger point adapts to the actual glucose level variations, performing invasive measurements only when the estimated level deviates significantly from the target, thereby reducing the frequency of painful procedures.
2Reliability
If invasive blood glucose measurement is performed frequently, then calibration data is updated often, but loss of time and increase in measurement frequency requirements
Solution Approach 1:
The system uses feedback from the estimated blood glucose level monitoring to determine when invasive measurement is necessary. By comparing the estimated level with the calibration target and triggering invasive measurement only when the difference exceeds the threshold, the system maintains reliable calibration data while minimizing time loss from unnecessary measurements.
3Ease of operation
If non-invasive measurement is used continuously, then ease of operation is improved, but measurement precision deteriorates due to lack of calibration
Solution Approach 1:
The system uses the estimated blood glucose level from non-invasive measurement as an intermediary to monitor calibration status. This intermediary value allows the system to determine when invasive measurement is needed for calibration, enabling continuous convenient non-invasive monitoring while maintaining precision through periodic invasive calibration updates.
Solution Approach 2:
The non-invasive measurement apparatus performs self-calibration monitoring by comparing its estimated blood glucose levels with target values. When calibration is needed, it automatically triggers the invasive measurement apparatus, allowing the system to maintain precision without requiring manual intervention for calibration.
Data Source
AI summary
A blood glucose measurement system in which a blood glucose level measured with an invasive blood glucose measurement apparatus 101 is used to calibrate a blood glucose level measured with a non-invasive blood glucose measurement apparatus 102, comprising a controller that outputs an invasive actuation signal that starts the detection of a characteristic quantity in the body with the invasive blood glucose measurement apparatus, and a blood sampling component for collecting blood from the body on the basis of the invasive actuation signal, wherein measurement with the invasive blood glucose measurement apparatus is begun when the amount of change in the estimated blood glucose level has reached or exceeded a non-invasive blood glucose threshold.