Integrated Glucose Dosing Control With Real-Time Sensitivity Feedback
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Solution Overview
Problem
Existing analyte monitoring systems in hospital or clinical settings face challenges in accurately determining analyte concentrations, particularly glucose levels, which can lead to health risks if not managed effectively, and lack efficient dosing protocols for treatment substances like insulin.
Innovation Solution
A patient treatment and analysis system that includes a body fluid analyzer, treatment dosing system, and communication interface to calculate and administer treatment dosages based on analyte concentration history, infusion information, and user input, with features for basal and bolus infusion modes, and adaptive dosing protocols.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a body fluid analyzer is used to measure analyte concentration, then measurement precision is improved, but device complexity increases
Solution Approach 1:
The patent combines the body fluid analyzer, treatment dosing system, and communication interface into an integrated system. The analyzer measures analyte concentration while the dosing system calculates and administers treatment dosages, with data flowing between components through the communication interface. This merging reduces overall system complexity by eliminating separate standalone devices while maintaining measurement precision.
Solution Approach 2:
The treatment dosing system serves multiple functions: it receives analyte concentration data from the analyzer, calculates treatment dosages based on patient-specific sensitivity and historical data, communicates with external infusion pumps, and provides real-time feedback. This multi-functionality consolidates what would otherwise require separate devices, reducing complexity while improving measurement and treatment coordination.
2Reliability
If adaptive dosing protocols are implemented, then treatment effectiveness is improved, but device complexity increases
Solution Approach 1:
The treatment dosing system implements adaptive dosing protocols that use real-time analyte concentration measurements and historical data to adjust treatment dosages. The system calculates patient-specific sensitivity factors and modifies dosing recommendations based on current glucose levels and response patterns. This feedback mechanism improves treatment effectiveness by dynamically adapting to patient needs while the automated calculation algorithms manage the complexity of the dosing logic.
Solution Approach 2:
The system pre-calculates patient-specific sensitivity factors and stores historical analyte concentration and dosage data for future reference. By preparing these calculations in advance and maintaining organized historical records, the system reduces the computational complexity required during real-time dosing decisions while improving treatment reliability through personalized protocols.
3Reliability
If real-time feedback and adaptive dosing are provided, then glycemic control is improved, but loss of time in data processing increases
Solution Approach 1:
The communication interface maintains continuous data flow between the body fluid analyzer, treatment dosing system, and external infusion pumps. Analyte concentration measurements are continuously fed into the dosing algorithm, which continuously updates treatment recommendations. This continuous processing eliminates batch processing delays and maintains rapid response times for glycemic control while providing uninterrupted real-time feedback to clinicians and patients.
Solution Approach 2:
The system pre-processes and stores historical analyte concentration and dosage data in organized formats that facilitate rapid retrieval and analysis. By preparing historical data and patient-specific sensitivity factors in advance, the system reduces the computational time required for real-time dosing calculations while maintaining accurate and reliable glycemic control through continuous adaptive dosing.
Data Source
AI summary
Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e.g. insulin, dextrose, etc.) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.