Glucose-Insulin Prediction via Probabilistic Excursion Detection

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Solution Overview

Problem

Current technologies face challenges in performing predictive data analysis for the glucose-insulin endocrine metabolic regulatory system, particularly in detecting glucose surge excursions and generating accurate glucose-insulin predictions.

Innovation Solution

The implementation of a probabilistic framework for detecting glucose surge excursions, combined with machine learning models such as steady-state glucose-insulin prediction models, to analyze continuous glucose monitoring data and generate predictive insights.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If traditional glucose monitoring methods are used, then device complexity is reduced, but measurement precision and predictive capability deteriorate

Engineering Contradiction:
Improveglucose surge excursion detection accuracyVSAvoidpredictive data analysis system complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system segments glucose monitoring into distinct phases: data collection from CGM devices, probabilistic excursion detection, machine learning-based prediction, and action generation. This segmentation allows complex predictive analysis to be performed only when needed (during excursions) rather than continuously, improving precision without proportionally increasing overall system complexity

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent introduces machine learning models as intermediaries between raw glucose data and clinical decisions. These models process and interpret complex glucose patterns, providing predictive insights that bridge the gap between simple monitoring data and sophisticated medical decision-making, thereby improving measurement precision through intelligent mediation

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If continuous predictive analysis is performed on all glucose data, then prediction accuracy is improved, but processing time and computational resources increase

Engineering Contradiction:
Improveglucose-insulin prediction accuracyVSAvoiddata processing time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The system performs preliminary probabilistic excursion detection to identify periods of significant glucose change before applying more computationally intensive machine learning prediction models. This preliminary filtering action ensures that full predictive analysis is only performed when excursions are detected, improving prediction reliability while minimizing unnecessary processing time during stable glucose periods

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent applies partial action by using probabilistic methods to detect excursions with a certain confidence threshold rather than analyzing every data point with full machine learning models. This approach achieves sufficient prediction accuracy for clinical decision-making while significantly reducing computational overhead and processing time compared to exhaustive analysis of all glucose data

Inventive Principle:
Principle #16Partial or excessive action

3Measurement precision

If probabilistic excursion detection is used, then detection accuracy is improved, but computational complexity increases

Engineering Contradiction:
Improveexcursion start and end time detection accuracyVSAvoidprobabilistic framework complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system changes parameters by using probabilistic thresholds for excursion detection rather than fixed deterministic values. This allows the detection algorithm to adapt to individual patient variability and different glucose patterns, improving detection precision while the probabilistic nature provides a mathematically tractable framework that manages computational complexity through statistical methods

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentUS20250090082A1Predictive monitoring of the glucose-insulin endocrine metabolic regulatory system
Publication Date: 2025.03.20 UNITEDHEALTH GROUP INC
  • US20250090082A1 patent drawing
  • US20250090082A1 patent drawing
  • US20250090082A1 patent drawing

AI summary

There is a need for more effective and efficient predictive data analysis, such as more effective and efficient data analysis solutions for performing predictive monitoring of the glucose-insulin endocrine metabolic regulatory system.