Non-invasive Blood Glucose Measurement via Acceleration Pulse Wave
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Solution Overview
Problem
Conventional non-invasive blood glucose level measurement methods using optical techniques often fail to meet practical requirements for measurement accuracy and are costly.
Innovation Solution
A non-invasive blood glucose level measurement device that utilizes acceleration pulse waves measured by fiber Bragg grating sensors, correlating these waves with invasive measurement data to extract glucose level information through a calibration curve constructed by PLS regression analysis, allowing for accurate and cost-effective glucose level prediction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If non-invasive blood glucose level measurement methods using optical techniques are used, then the psychological burden and economic burden are reduced, but the measurement accuracy does not stably meet practical requirements
Solution Approach 1:
The patent replaces optical measurement systems with a mechanical sensing system. Specifically, it uses a piezoelectric sensor to detect pulse wave signals mechanically, rather than using optical techniques. This mechanical approach to detecting physiological signals provides more stable and accurate measurements while maintaining the non-invasive benefit, thus resolving the contradiction between reducing psychological burden and maintaining measurement accuracy.
2Object-affected harmful factors
If non-invasive blood glucose level measurement methods using optical techniques are used, then the psychological burden and economic burden are reduced, but the equipment costs are high
Solution Approach 1:
The patent employs a cost-effective sensing approach using a piezoelectric sensor that is simpler and more economical than complex optical measurement systems. The device uses basic signal processing and a calibration curve based on pulse wave characteristics rather than expensive optical components, thereby reducing equipment costs while maintaining the non-invasive advantage.
3Measurement precision
If invasive blood glucose level measurement methods are used, then the measurement accuracy is high, but the psychological burden and economic burden increase
Solution Approach 1:
The patent introduces an intermediary approach by using pulse wave signals as a mediator to indirectly measure blood glucose levels. Instead of directly measuring glucose through invasive blood sampling, the system detects pulse wave characteristics and uses a calibration curve to estimate blood glucose levels. This intermediary method maintains high measurement accuracy while eliminating the psychological burden of invasive procedures.
4Device complexity
If non-invasive blood glucose level measurement methods using optical techniques are used, then the equipment costs are reduced compared to invasive methods, but the measurement accuracy does not meet practical requirements
Solution Approach 1:
The patent changes the measurement parameter from direct optical absorption measurements to pulse wave signal characteristics. By detecting temporal and amplitude parameters of pulse waves using a piezoelectric sensor and applying a calibration curve, the system achieves meeting practical accuracy requirements with simpler, more cost-effective equipment compared to complex optical systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device achieves measurement accuracy comparable to invasive methods while being more cost-effective than conventional non-invasive optical techniques, with a calibration accuracy of ±15 mg/dL over a blood glucose range of 80 to 178 mg/dL and high time resolution.
Implementation Method 1
an acceleration pulse wave of a test subject is measured utilizing a fiber Bragg grating sensor
Data Source
Figure 1
Figure 2.1
Figure 2.2(a)~2.2(b)
AI summary
The non-invasive blood glucose level measurement device (1) is provided with a pulse waveform measurement unit (2) having FBG sensors (4) for measuring an acceleration pulse wave of a test subject; and a data-processing unit (3) for calculating the blood glucose level of the test subject at the point in time of measurement of the acceleration pulse wave, from waveform information of the measured acceleration pulse wave, on the basis of a predetermined correlation. The correlation is a calibration curve constructed by carrying out a PLS regression analysis, using the blood glucose level measured by a non-invasive blood glucose method as the objective variable, and a simultaneously-measured acceleration pulse wave as the explanatory variable. A non-invasive blood glucose level measurement device capable of measuring blood glucose level at about the same measurement accuracy as an invasive blood glucose measurement device can be achieved thereby.