Glucose Sensor Calibration Timing Control
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Solution Overview
Problem
The existing Continuous Glucose Monitoring (CGM) systems face accuracy issues due to a time lag between blood glucose levels and interstitial fluid glucose concentrations, leading to inaccurate calibration when blood glucose levels fluctuate rapidly.
Innovation Solution
A measuring apparatus that includes a measuring unit for signal values in interstitial fluid, an acquiring unit for reference values from blood samples, a calculation unit to determine concentration variations, and an output unit to recommend or not recommend calibration based on these variations, thereby improving measurement accuracy without displaying glucose concentration values to the patient.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If calibration is performed using blood glucose level measured at arbitrary timing, then calibration can be implemented, but measurement accuracy deteriorates when blood glucose level varies significantly
Solution Approach 1:
The system dynamically determines calibration timing by monitoring the variation magnitude of blood glucose levels. The determination unit assesses whether the blood glucose level variation exceeds a predetermined threshold, and the calibration execution unit selectively performs calibration only when variation is within acceptable ranges. This dynamic adaptation resolves the contradiction by making calibration frequency responsive to actual physiological conditions rather than following a fixed schedule.
Solution Approach 2:
The system changes the parameter of calibration timing based on the measured blood glucose level variation. By using the variation magnitude as a control parameter, the system decides whether to proceed with calibration. This parameter-based decision-making allows the system to maintain measurement accuracy by avoiding calibration during periods of significant physiological change while still performing calibration when conditions are favorable.
2Object-affected harmful factors
If glucose concentration value is displayed on display device, then patient awareness of blood glucose variation is reduced, but calibration timing cannot be optimized
Solution Approach 1:
The system introduces an intermediary determination unit that acts as a mediator between the blood glucose measurement and the calibration execution. This determination unit independently assesses the suitability of calibration timing by evaluating blood glucose variation magnitude, separating the calibration decision-making process from patient display information. This intermediary layer enables optimized calibration timing without requiring changes to patient-facing display functionality.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution enhances the accuracy of glucose concentration measurements in interstitial fluid by recommending calibration only when variations are within acceptable thresholds, reducing the impact of time lags and fluctuations in blood glucose levels.
Implementation Method 1
a micro sensor including electrodes and enzyme reacting to the glucose
Implementation Method 2
a micro sensor including electrodes and enzyme reacting to the glucose
Data Source
AI summary
A measuring apparatus includes: a measuring unit to measure a signal value corresponding to a concentration of a specified substance contained in a first sample; an acquiring unit to acquire a reference value pertaining to the specified substance contained in a second sample; a calculation unit to calculate a concentration value of the specified substance contained in the first sample, based on the signal value and the reference value; a determination unit to determine whether a variation in the concentration value of the specified substance contained in the first sample is equal to or less than a threshold value; and an output unit to output, to a display unit, recommendation information representing recommendation for acquiring the reference value when the variation in the concentration value of the specified substance contained in the first sample is equal to or less than the threshold value.