Glucose Sensor Calibration via Dual Temperature Monitoring
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing methods for measuring glucose concentration using subcutaneous electrochemical sensors face challenges in maintaining reliability due to fluctuations in ambient temperature, affecting the accuracy of glucose concentration measurements in both blood and interstitial fluid.
Innovation Solution
An analysis apparatus and method that includes signal detection, temperature detection, and calculation units to continuously monitor and calibrate glucose concentration measurements by referencing temperature values from both the subcutaneously detected sample and a separately measured sample, ensuring accurate results even under large temperature fluctuations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If subcutaneous electrochemical sensor is used for continuous glucose concentration measurement, then continuous monitoring capability is improved, but measurement reliability deteriorates due to temperature fluctuations
Solution Approach 1:
The patent implements a feedback mechanism where temperature detection units continuously monitor temperature values, and the calculation unit uses these temperature values to correct glucose concentration measurements. The system feeds back corrected measurement results to maintain accuracy despite temperature variations, resolving the contradiction between continuous monitoring and measurement reliability.
Solution Approach 2:
The patent changes the measurement parameters by introducing temperature compensation. The calculation unit adjusts glucose concentration values based on detected temperature values, effectively changing the measurement parameter from raw current signal to temperature-corrected concentration, thereby maintaining reliability under varying temperature conditions.
2Measurement precision
If calibration is performed using blood glucose values, then measurement accuracy is improved, but system complexity increases due to multiple sample requirements
Solution Approach 1:
The patent makes the measurement system universal by enabling it to handle multiple sample types (interstitial fluid from subcutaneous sensor and blood from separate measurement). The system can perform both continuous interstitial fluid monitoring and periodic blood-based calibration, reducing overall system complexity through multi-functionality.
Solution Approach 2:
The patent applies preliminary action by performing blood-based calibration at predetermined intervals before continuous interstitial fluid measurement. This preliminary calibration establishes accurate baseline values that the continuous monitoring system then references, improving measurement precision without requiring complex real-time blood monitoring.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances the reliability of glucose concentration measurements by effectively calibrating results based on temperature variations, providing accurate numerical value information under conditions of significant ambient temperature fluctuations.
Implementation Method 1
The electrochemical sensor for detecting a specified component in a sample by making use of enzyme reaction in a way that immobilizes the enzyme to a subcutaneously detained sensor unit
Implementation Method 2
The glucose concentration is measured based on a response current acquired by continuously applying a fixed voltage (e.g., about 0.3V - 0.6V) to between the working electrode and the counter electrode
Implementation Method 3
a first temperature detection unit to capture a first temperature value defined as temperature information on the first sample; a second temperature detection unit to capture a second temperature value defined as temperature information on the second sample
Implementation Method 4
a calculation unit to calibrate to the numerical value information on the specified substance in the first sample from the signal value by referring to the numerical value information on the specified substance in the second sample in accordance with the first temperature value and the second temperature value
Data Source
Figure 1
Figure 2
Figure 3
AI summary
Provided is a technology capable of acquiring a measurement result with high reliability under a condition exhibiting a large fluctuation in ambient temperature when measuring numerical value information on a specified substance in a sample. An analysis apparatus includes: a signal detection unit to continuously detect signal values detected from a first sample; a measuring unit to measure numerical value information on a specified substance in a second sample; a first temperature detection unit to capture a first temperature value defined as temperature information on the first sample; a second temperature detection unit to capture a second temperature value defined as temperature information on the second sample; and a calculation unit to calibrate to the numerical value information on the specified substance in the first sample from the signal value by referring to the numerical value information on the specified substance in the second sample in accordance with the first temperature value and the second temperature value.