Glucose Sensor Filter with Piezoelectric Cleaning
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Solution Overview
Problem
Existing glucose sensors face measurement accuracy issues due to interference from substances like microorganisms, proteins, and lipids, which can adhere to the sensor and hinder the detection of glucose, even when antifungal agents or antibiotics are used to prevent adhesion.
Innovation Solution
A sensor design featuring a filter that allows glucose to pass while blocking interfering substances, combined with a piezoelectric element that vibrates to remove adhered substances, ensuring continuous and accurate glucose monitoring.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a filter is introduced to block interfering substances, then measurement precision is improved, but device complexity increases
Solution Approach 1:
The sensor is divided into distinct functional layers: a detecting unit for glucose detection and a filter layer for blocking interfering substances. This segmentation allows each component to perform its specific function independently, improving measurement precision while keeping the overall structure manageable through clear functional separation.
2Productivity
If the subcutaneous retention period is prolonged, then productivity is improved, but interfering substances gradually adhere to the electrode, worsening measurement precision
Solution Approach 1:
A filter layer is introduced in advance to prevent interfering substances from reaching and adhering to the electrode during the retention period. This preliminary protective action allows the sensor to maintain measurement precision throughout the extended subcutaneous retention period, enabling prolonged productivity without accuracy degradation.
3Reliability
If antifungal agents or antibiotics are mixed with the enzyme, then reliability is improved, but measurement precision deteriorates due to interference from adhered substances over time
Solution Approach 1:
A filter layer is introduced as an intermediary component between the sample and the detecting unit. This filter acts as a physical barrier that blocks interfering substances (proteins, fibrin, lipids) from reaching the enzyme and electrode, while still allowing glucose to pass through. This intermediary structure maintains measurement precision over time without relying solely on chemical agents that may lose effectiveness.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively prevents harmful interference, maintaining measurement accuracy over extended periods by periodically removing adhered substances from the filter, thus preventing clogging and ensuring smooth glucose detection.
Implementation Method 1
the removing means includes: a piezoelectric element which is vibrated by applying a voltage; and vibration transmitting means which is fixed to the piezoelectric element and which is configured to transmit vibrational energy of the piezoelectric element to the filter
Implementation Method 2
a filter which covers the detecting unit, which permits permeation of the objective substance on one hand, and which regulates permeation of an interfering substance contained in the sample on the other hand
Data Source
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AI summary
A technique is provided, wherein any influence, which would be otherwise exerted on a reaction of an objective substance caused by a reagent enzyme by an interfering substance contained in a specimen, is suppressed in relation to an electrochemical sensor for measuring the objective substance contained in the specimen. A sensor comprises a substrate; a detecting unit which is provided on the substrate and which detects an objective substance; a filter which covers the detecting unit, which permits permeation of the objective substance on one hand, and which regulates permeation of an interfering substance contained in a sample on the other hand; and removing means which removes the interfering substance adhered to the filter.