Glucose Sensor Hydration Detection via Open Circuit Potential

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Solution Overview

Problem

Current glucose sensors require a lengthy stabilization period before providing accurate readings, and there is no automated method to determine when the sensor electrodes are sufficiently hydrated, leading to inconvenient waiting times for users and potential damage if power is applied too early.

Innovation Solution

A method and system that measure the open circuit potential between sensor electrodes to determine the point of hydration and calculate the rate of change over time, using a hydration detection circuit to ensure electrodes are adequately hydrated before applying power, thereby reducing stabilization time and preventing damage.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If a lengthy stabilization period is required for glucose sensors, then accurate readings can be obtained, but user convenience deteriorates and stabilization time increases

Engineering Contradiction:
Improvereading accuracyVSAvoidstabilization time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The system performs preliminary hydration detection by measuring open circuit potential before applying power to the sensor. This preliminary action determines the optimal timing for power application, ensuring electrodes are sufficiently hydrated without requiring lengthy stabilization periods. The hydration status is assessed in advance, allowing immediate accurate measurements once powered.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system continuously monitors the open circuit potential between sensor electrodes to feedback on hydration status. Based on this feedback, the system dynamically determines when to apply power, optimizing the balance between ensuring adequate hydration and minimizing stabilization time. The feedback mechanism allows adaptive control of power application timing.

Inventive Principle:
Principle #23Feedback

2Loss of time

If power is applied immediately to the sensor, then stabilization time is reduced, but electrode damage may occur due to insufficient hydration

Engineering Contradiction:
Improvestabilization timeVSAvoidelectrode damage
Core Design Contradiction:
Loss of timeVSObject-affected harmful factors

Solution Approach 1:

The system performs preliminary hydration assessment by measuring open circuit potential before power application. This preliminary check ensures electrodes are sufficiently hydrated, preventing damage while enabling immediate or shortened stabilization periods. The detection occurs in advance, creating a safety barrier against premature power application.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The open circuit potential measurement serves as an intermediary indicator of electrode hydration status. Instead of directly measuring hydration or relying on fixed time delays, the system uses this intermediary parameter to determine the appropriate timing for power application, balancing safety and speed.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Object-affected harmful factors

If manual waiting time is required for sensor hydration, then electrode damage can be prevented, but ease of operation deteriorates and user responsibility increases

Engineering Contradiction:
Improveelectrode damage preventionVSAvoiduser convenience
Core Design Contradiction:
Object-affected harmful factorsVSEase of operation

Solution Approach 1:

The system performs self-diagnosis of electrode hydration status through automatic open circuit potential measurement. The sensor system monitors its own hydration state and determines when power application is safe, eliminating the need for manual user intervention or waiting. The system serves itself by detecting and reporting hydration status automatically.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The system provides automatic feedback on hydration status through continuous monitoring of open circuit potential. This feedback is communicated to the user without requiring manual checking, and the system uses this feedback to automatically determine optimal power application timing, greatly simplifying user interaction while maintaining electrode protection.

Inventive Principle:
Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach significantly reduces the stabilization time of glucose sensors, ensuring accurate readings are obtained promptly while preventing electrode damage by automating the hydration detection process.

Implementation Method 1

measuring a open circuit potential between at least two of the plurality of electrodes

Methodology Applied
Scientific EffectOpen circuit potential measurement: Electric Field

Data Source

PatentEP2229095B1System and method for determining the point of hydration and proper time to apply potential to a glucose sensor
Publication Date: 2012.09.05 MEDTRONIC MINIMED INC
  • EP2229095B1 patent drawingFigure 1
  • EP2229095B1 patent drawingFigure 2A
  • EP2229095B1 patent drawingFigure 2B

AI summary

According to an embodiment of the invention, a method of determining hydration of a sensor having a plurality of electrodes is disclosed. In particular embodiments, the method couples a sensor electronics device to the sensor and measures the open circuit potential between at least two of the plurality of electrodes. Then, the open circuit potential measurement is compared to a predetermined value. In some embodiments, the plurality of electrodes includes a working electrode, a reference electrode, and a counter electrode. In still further embodiments, the open circuit potential between the working electrode and the reference electrode is measured. In other embodiments, the open circuit potential between the working electrode and the counter electrode is measured. In still other embodiments, the open circuit potential between the counter electrode and the reference electrode is measured.