Glucose Sensor Interferent Detection for Accurate Continuous Monitoring
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Solution Overview
Problem
Current blood glucose monitoring methods, such as finger-stick tests, are burdensome and provide limited information about intraday fluctuations, while continuous glucose monitors (CGMs) do not effectively account for interferents like insulin, which can interfere with accurate glucose measurements.
Innovation Solution
An analyte monitoring system that includes an analyte sensor with integrated analyte and interferent indicators and detectors, capable of distinguishing between glucose and interferents like insulin, using distinct excitation wavelengths to emit and detect emission light, allowing for accurate analyte level calculations in interstitial fluid and blood.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If continuous glucose monitoring is implemented, then measurement frequency and characterization of glucose fluctuations are improved, but measurement precision deteriorates due to interferent interference
Solution Approach 1:
The patent introduces interferent indicators as intermediary substances that mediate between the interferents (insulin, hemoglobin) and the detection system. These indicators specifically bind to interferents and produce distinct optical signals, allowing the system to distinguish interferent effects from glucose signals, thereby maintaining measurement precision while enabling continuous monitoring
Solution Approach 2:
The patent employs multiple excitation wavelengths as varying parameters to differentiate between glucose and interferents. By measuring optical responses at different wavelengths and analyzing the spectral characteristics, the system can distinguish between analyte and interferent signals, maintaining measurement precision across continuous monitoring
2Measurement precision
If interferent detection is added to the analyte sensor, then measurement precision is improved by accounting for interferents, but device complexity increases
Solution Approach 1:
The patent merges the analyte detection and interferent detection functions into a single integrated sensor device. The analyte indicator and interferent indicators are incorporated into the same sensor structure, sharing common components such as the optical waveguide and detection electronics, thereby reducing overall device complexity while maintaining measurement precision
Solution Approach 2:
The sensor device is designed with multi-functionality, serving both as an analyte monitor and an interferent detector. The optical detection system is configured to simultaneously measure multiple parameters (analyte concentration and interferent levels) using the same hardware platform, avoiding the need for separate devices and reducing complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances the accuracy of glucose monitoring by accounting for interferents, providing continuous and precise glucose level measurements, thereby improving glycemic control and patient outcomes.
Implementation Method 1
the analyte indicator may be configured to, in response to being irradiated with the analyte excitation light, emit analyte emission light indicative of the analyte level in the first medium
Data Source
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AI summary
Analyte monitoring methods and systems for interferent detection. The methods may include using one or more analyte detectors of an analyte sensor to generate one or more analyte measurements indicative of an analyte level in a first medium. The methods may include using one or more interferent detectors of the analyte sensor and/or one or more interferent sensors of a transceiver to generate one or more interferent measurements indicative of an interferent level in the first medium. The methods may include using a transceiver interface of the analyte sensor to convey the one or more analyte measurements and using a sensor interface of the transceiver to receive the one or more analyte measurements from the analyte sensor. The methods may include using the transceiver to calculate an analyte level in a second medium using at least the one or more analyte measurements and the one or more interferent measurements.