Continuous Glucose Sensor Calibration via Reference Data Matching
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Solution Overview
Problem
Conventional glucose sensors for diabetes management are plagued by inaccuracies and discomfort, with implantable sensors providing short-term and less-than-accurate readings, and transdermal sensors struggling to continuously and accurately monitor blood glucose levels over extended periods, leading to delayed detection of hyperglycemic or hypoglycemic conditions.
Innovation Solution
A method and system for calibrating analyte sensors by matching sensor data with reference data to rapidly convert glucose values, allowing for immediate and subsequent calibration without compensating for time lags, enabling timely and accurate glucose monitoring through a processor module that displays estimated analyte values within minutes of receiving reference values.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional self-monitoring blood glucose (SMBG) methods are used, then the diabetic can obtain glucose readings, but the measurements are delayed and insufficient for timely detection of hyperglycemic or hypoglycemic conditions
Solution Approach 1:
The patent replaces the mechanical finger-pricking SMBG method with an implantable continuous glucose sensor that uses electrochemical detection. The sensor continuously monitors glucose levels in interstitial fluid, eliminating the need for repeated manual blood sampling and providing real-time data without time delays.
Solution Approach 2:
The patent implements continuous glucose monitoring through an implantable sensor that operates continuously rather than intermittently. The sensor provides uninterrupted glucose level measurements, enabling real-time detection of glycemic changes and eliminating the gaps between discrete SMBG measurements.
2Duration of action of stationary object
If implantable glucose sensors are used for continuous monitoring, then real-time glucose data can be obtained, but the sensors provide only short-term and less-than-accurate readings
Solution Approach 1:
The patent applies preliminary calibration procedures before the sensor is fully deployed for continuous monitoring. By performing initial calibration with reference blood glucose measurements and establishing baseline relationships, the sensor achieves accurate readings from the start of continuous operation, avoiding the accuracy degradation that would otherwise occur over time.
Solution Approach 2:
The patent employs algorithms that dynamically adjust sensor parameters and calibration factors based on changing physiological conditions and sensor drift. By continuously optimizing measurement parameters and compensating for sensor degradation, the system maintains high accuracy throughout the extended monitoring duration.
3Duration of action of stationary object
If transdermal sensors are used for continuous glucose monitoring, then extended period monitoring is achieved, but the sensors struggle to accurately sense and report glucose values
Solution Approach 1:
The patent replaces transdermal optical or chemical sensing methods with an implantable electrochemical sensor. The implantable sensor directly contacts interstitial fluid through a small implantation site, providing more reliable and accurate glucose measurements compared to transdermal approaches that must penetrate the skin barrier and are susceptible to environmental interference.
Solution Approach 2:
The patent uses advanced signal processing algorithms that dynamically adjust measurement parameters and compensate for various sources of error including temperature variations, pH changes, and sensor drift. These real-time parameter adjustments maintain measurement accuracy throughout extended monitoring periods despite changing physiological conditions.
4Loss of time
If rapid calibration without time lag compensation is performed, then timely glucose values are obtained, but conventional methods require time lag compensation which delays results
Solution Approach 1:
The patent performs preliminary calibration procedures that establish the relationship between sensor readings and reference blood glucose values before clinical use. By pre-calibrating the sensor with multiple reference measurements and establishing baseline conversion factors, the system eliminates the need for time-lag compensation during operation, providing immediate accurate results.
Solution Approach 2:
The patent uses matched data pairs from calibration procedures to create a reference model that copies the relationship between sensor signals and actual glucose concentrations. This pre-established model allows direct conversion of sensor readings to accurate glucose values without requiring time-lag compensation or complex real-time adjustments.
Data Source
AI summary
Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided.