Glucose Sustained-Release Pellets for Stable Blood Sugar
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Solution Overview
Problem
Current treatments for glycogen storage disease, such as raw corn starch therapy, are cumbersome, have low patient compliance, and result in unstable glucose levels due to frequent dosing, digestive intolerance, and variability in corn starch quality, limiting their effectiveness.
Innovation Solution
Development of glucose sustained-release pellets with a suitable particle size and smooth surface, composed of anhydrous glucose, microcrystalline cellulose, and a binder, which release glucose slowly and continuously, maintaining stable blood sugar levels and improving treatment compliance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If raw corn starch therapy is used to treat glycogen storage disease, then glucose can be released in the body, but the treatment requires frequent dosing which reduces patient compliance
Solution Approach 1:
The invention segments the glucose delivery system into controlled-release pellets with specific size ranges (0.5-2.0mm diameter). This segmentation allows the glucose to be released in a controlled manner over an extended period, reducing the frequency of dosing while maintaining effective glucose release for treating glycogen storage disease.
2Reliability
If raw corn starch therapy is used, then glucose release occurs, but digestive intolerance and variability in corn starch quality result in unstable glucose levels
Solution Approach 1:
The invention changes the physical and chemical parameters of the glucose delivery system by using purified glucose as the core material instead of raw corn starch, and by controlling the particle size and composition of the release pellets. This ensures consistent and stable glucose release rates, eliminating the variability associated with corn starch quality while maintaining effective glucose release.
3Reliability
If conventional glucose delivery methods are used, then glucose can be administered, but frequent dosing and cumbersome administration reduce treatment convenience
Solution Approach 1:
The invention implements continuous glucose release through specially designed pellets that maintain a steady release rate over an extended period. This continuous action eliminates the need for frequent dosing, providing uninterrupted glucose supplementation for patients with glycogen storage disease while significantly improving treatment convenience and patient compliance.
Data Source
AI summary
The invention belongs to the field of biomedicine, and particularly relates to a glucose core, comprising a glucose and/or a glucose hydrate, a diluent and a binder, wherein, the glucose and/or the glucose hydrate is present in the glucose core in an amount of ≤85% by weight percentage; and relates to a glucose pellet comprising the glucose core and a laminated layer coating the glucose core; and further relates to a pharmaceutical composition comprising the glucose pellet. The glucose pellet or the pharmaceutical composition of the invention are useful in treatment and/or assistant treatment of a glycogen storage disease and/or a diabetes.