Disposable Glucose Test Strip with CMOS Sensor
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Solution Overview
Problem
Conventional blood glucose measurement devices are cumbersome, complex, and require frequent enzyme sensor replacements, making them inconvenient for real-time monitoring in everyday environments.
Innovation Solution
A portable blood glucose measurement unit with a transparent substrate system, including a blood inflow region, reaction region, and a CMOS image sensor, using a reagent such as O-dianisidine and glucose oxidase to measure glucose levels, which can be integrated with smartphones for easy and accurate real-time monitoring.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional enzymatic method is used for blood glucose measurement, then measurement accuracy is maintained, but device complexity increases and requires frequent sensor replacement
Solution Approach 1:
The patent extracts the enzyme sensor component from the measurement device, replacing it with a disposable test strip containing reagents. This eliminates the need for frequent sensor replacements while maintaining measurement accuracy, as the test strip is discarded after use rather than requiring sensor recalibration or replacement.
Solution Approach 2:
The patent employs disposable test strips instead of durable but complex enzyme sensors. The test strip contains all necessary reagents (glucose oxidase, peroxidase, chromogen) in a disposable format, eliminating device complexity while maintaining reliable measurements through chemical reactions rather than electronic sensing.
2Productivity
If conventional glucose measurement device is used, then measurement function is provided, but portability deteriorates due to large volume
Solution Approach 1:
The patent segments the measurement system into two independent parts: a handheld lancing device for blood collection and a separate test strip for measurement. This segmentation allows each component to be miniaturized, with the test strip being particularly compact, thereby improving portability while maintaining full measurement functionality.
Solution Approach 2:
The patent replaces bulky mechanical/electronic sensing systems with a chemical reaction-based measurement system. The test strip uses chemical reagents (glucose oxidase, peroxidase, chromogen) that produce color changes in response to glucose concentration, eliminating the need for complex electronic sensors and associated hardware, thus reducing device volume.
3Productivity
If conventional measurement device is used, then blood glucose can be measured, but ease of operation deteriorates due to complicated structure
Solution Approach 1:
The patent implements self-service through the disposable test strip design, where all necessary reagents and measurement components are pre-loaded into the strip. The user simply applies blood to the test strip, and the chemical reactions automatically occur without requiring user intervention for sensor calibration, electrode maintenance, or electronic configuration, thereby greatly simplifying operation.
Solution Approach 2:
The patent extracts all complex measurement functionality from the user's perspective and embeds it into the disposable test strip. The test strip contains pre-positioned reagents and measurement elements that automatically perform the measurement function when blood is applied, removing the need for users to interact with complex device structures or perform manual calibration procedures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables convenient, real-time blood glucose monitoring with improved portability and accuracy using a smartphone-integrated CMOS image sensor, allowing for effective glucose level tracking without the need for frequent sensor replacements.
Implementation Method 1
glucose oxidase
Implementation Method 2
react with the glucose in the blood
Implementation Method 3
reagent distributed to the reaction region so as to react with the glucose in the blood
Data Source
AI summary
A blood glucose measurement unit, a blood glucose measurement method, and a blood glucose measurement system comprising the same are disclosed. According to one aspect of the present invention, provided is a blood glucose measurement unit comprising: a transparent first substrate consisting of a blood inflow region into which blood flows and a reaction region connected to the blood inflow region which are formed on one surface thereof; a transparent second substrate coupled to the first substrate and comprising a blood aperture through which the blood flowing into the blood inflow region passes; and a reagent distributed to the reaction region so as to react with the blood glucose of the blood which has flown into the blood inflow region.