Glucuronic Acid Bone Graft Composition for Rapid Setting Stability
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Solution Overview
Problem
Existing bone graft materials face issues of low biocompatibility, potential disease transmission, high cost, slow resorption, pH-related inflammation, and challenges in precise application, especially in the oral cavity.
Innovation Solution
A composition comprising glucuronic acid-1-phosphate, tetracalcium phosphate, and cross-linked collagen, with specific weight ratios and particle sizes, providing a biocompatible, rapidly setting, and mechanically stable bone graft material.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If adhesive materials are used to provide strong adhesion and rapid setting, then bond strength and setting speed are improved, but pH-related inflammation and cytotoxic effects occur
Solution Approach 1:
The patent modifies the chemical composition parameters of the adhesive material by incorporating specific ratios of calcium phosphate particles (0.1-1 mm size) and collagen fibers, along with controlled release acidifiers, to adjust the pH profile and reduce cytotoxic effects while maintaining bond strength
Solution Approach 2:
The invention creates a composite adhesive material combining calcium phosphate particles, collagen fibers, and water-soluble polymers in specific proportions (60-90 wt% calcium phosphate, 5-30 wt% collagen fibers) to achieve both strong adhesion and biocompatibility
2Duration of action of stationary object
If adhesive degradation is slowed to maintain bond strength, then adhesion durability is improved, but natural bone replacement time increases and complication risk rises
Solution Approach 1:
The patent designs the adhesive with dynamic degradation characteristics through the inclusion of collagen fibers and controlled release acidifiers that allow the material to maintain strength initially then progressively degrade as bone regenerates, optimizing both durability and timely replacement
Solution Approach 2:
The adhesive formulation includes pre-configured collagen fiber networks and calcium phosphate particle distributions that prepare the material structure for controlled degradation, allowing predictable timing of bond strength maintenance followed by gradual resorption
3Reliability
If animal-derived bone graft materials are used to provide scaffolding and volume maintenance, then biocompatibility and bone regeneration support are improved, but disease transmission risk and cost increase
Solution Approach 1:
The patent employs synthetic, biodegradable polymers and naturally occurring but processed materials (collagen from controlled sources, calcium phosphate) that eliminate disease transmission risks while maintaining biocompatibility, replacing the need for long-lasting animal-derived materials
Solution Approach 2:
The invention modifies material parameters by using cross-linked collagen fibers and specific calcium phosphate particle size distributions (0.1-1 mm) to achieve appropriate degradation rates and mechanical properties without requiring animal-derived components
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition offers immediate primary stability, rapid setting, and enhanced mechanical stability, addressing biocompatibility and application precision issues, while supporting bone regeneration and drug delivery.
Implementation Method 1
The compositions include at least tetra calcium phosphate, an effective amount of a compound that is structurally similar to phosphoserine
Implementation Method 2
They can be mixed with an aqueous solution... rapid setting
Data Source
Figure 1
Figure 2~2A
Figure 3~3A
AI summary
A composition comprising glucuronic acid-1-phosphate, tetracalcium phosphate, cross-linked collagen and water. The composition has preferably the weight ratio Liquid/Powder of 0.18. The composition is used in producing a bone graft and in other dental and medical applications. A process for producing the composition.