Glutamine Composition for Brain Damage and Cognitive Impairment

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Solution Overview

Problem

Current treatments for mild cognitive impairment and brain damage lack effective compositions that utilize glutamine as a key component, despite its potential benefits in metabolic processes and energy supply in the brain.

Innovation Solution

A composition incorporating glutamine or its pharmaceutically acceptable salt is developed for use in functional health food, pharmaceutical, and quasi-drug forms, which is administered to prevent, ameliorate, or treat brain damage and mild cognitive impairment, shown to enhance cognitive abilities and reduce oxidative stress in animal models.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional treatments (choline esterase inhibitors, anti-oxidizing agents, NMDA receptor antagonists) are used for mild cognitive impairment, then cognitive function can be partially improved, but the treatments do not effectively prevent progression to Alzheimer's disease and have limited efficacy

Engineering Contradiction:

Improveeffectiveness of treatmentVSAvoidneed for multiple drug types

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent combines glutamine with specific excipients to create a unified composition that addresses multiple aspects of cognitive impairment simultaneously. This single composition integrates the benefits of glutamine supplementation with formulation elements that enhance stability and bioavailability, replacing the need for multiple separate drug treatments.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent optimizes the concentration and formulation parameters of glutamine within the composition to achieve enhanced efficacy. By carefully controlling the amount of glutamine and its interaction with excipients, the composition achieves better cognitive protection and prevention of Alzheimer's progression compared to conventional dosing approaches.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If glutamine is administered to prevent brain damage and mild cognitive impairment, then cognitive ability is maintained and neuronal damage is suppressed, but the mechanism of action requires understanding of metabolic processes and oxidative stress reduction

Engineering Contradiction:

Improvecognitive function maintenanceVSAvoidcomplexity of metabolic mechanisms

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent identifies and utilizes glutamine as an intermediary substance that mediates between dietary intake and brain health outcomes. Glutamine serves as a key metabolic intermediate that reduces oxidative stress, protects neurons, and supports cognitive function, bridging the gap between simple supplementation and complex neurological benefits.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Measurement precision

If stress is applied to induce brain damage and mild cognitive impairment in animal models, then cognitive deficits are observed, but the progression to severe neurological disorder remains uncertain

Engineering Contradiction:

Improvecognitive deficit detectionVSAvoidprediction of Alzheimer's progression

Core Design Contradiction:

Measurement precisionVSReliability

Solution Approach 1:

The patent applies glutamine supplementation before and during the stress induction period in animal models, performing preliminary protective action that prevents cognitive deficits from developing. This preventive approach, rather than reactive treatment after damage occurs, demonstrates enhanced cognitive protection and reduces the likelihood of progression to severe neurological disorders.

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The glutamine-based composition maintains cognitive abilities comparable to normal levels, suppresses neuronal damage, reduces ROS/RNS content, and enhances synaptic plasticity, effectively addressing brain damage and mild cognitive impairment, including in animal models of Alzheimer's disease.

Implementation Method 1

glutamine is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia, and it is a main transporter of nitrogen in human body and serves as an important energy source in various cells

Methodology Applied

Scientific EffectMetabolic process:

Implementation Method 2

STR+Gln group shows lower content of ROS/RNS and other related proteins in brain tissues

Methodology Applied

Scientific EffectOxidative stress reduction:

Data Source

PatentUS20230310356A1Composition for preventing, ameliorating, or treating brain damage and mild cognitive impairment comprising glutamine as effective component

Publication Date: 2023.10.05 INDUSTRYACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY

AI summary

A method for ameliorating or treating brain damage and mild cognitive impairment includes administering a composition including glutamine or a salt thereof as effective component to a subject in need thereof. Glutamine as the effective component not only can restore the memory and cognitive ability impaired by stress but also can suppress a damage on nerve cells, reduce the amount of ROS/RNS and other related proteins in brain tissues, and enhance synaptic plasticity. When the animal model of Alzheimer's disease is fed with glutamine, cognitive ability of the animal is improved and accumulation of Aβ42 is suppressed.