Glutamine Composition for Capillary Blood Flow Without Pressure Drop

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Solution Overview

Problem

Current methods for increasing blood flow in capillary vessels often result in side effects such as lowered systemic blood pressure, and dietary arginine does not effectively induce vasodilation without high dosages or combination with other substances.

Innovation Solution

Administering glutamine within a specific dosage range (25 mg/kg to 150 mg/kg body weight) along with pyrrolidone carboxylic acid and its derivatives to increase blood flow in capillary vessels, particularly in the liver and brain, while avoiding systemic blood pressure reduction.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If arginine is administered at high dosage to increase blood flow, then blood flow in capillary vessels increases, but systemic blood pressure is lowered

Engineering Contradiction:

Improveblood flowVSAvoidlowered systemic blood pressure

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameter by using glutamine instead of arginine as the active substance. Glutamine has been shown to increase blood flow through capillary vessels without causing the harmful side effect of systemic blood pressure reduction, thus resolving the contradiction between improving blood flow and avoiding harmful effects

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs a safe, naturally occurring amino acid (glutamine) that can be easily administered without the need for high dosages or combination with other substances, providing a simple and safe solution compared to complex arginine-based approaches

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Productivity

If arginine is administered to induce vasodilation, then blood flow increases, but high dosage or combination with other substances is required

Engineering Contradiction:

Improveblood flowVSAvoiddosage requirement

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The patent uses glutamine, a simple and safe substance that can be administered alone at moderate dosages without requiring combination with other vasodilating substances, thereby simplifying the treatment approach while maintaining effectiveness

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent changes the substance from arginine to glutamine, which has different pharmacological properties allowing it to increase blood flow without requiring high dosages or combination therapies, thus reducing complexity

Inventive Principle:

Principle #35Parameter changes

3Productivity

If calcium antagonists or cellular respiration activators are used to increase blood flow, then blood flow in capillary vessels increases, but side effects occur

Engineering Contradiction:

Improveblood flowVSAvoidside effects

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent employs glutamine, a naturally occurring amino acid that is safe for use and does not cause the harmful side effects associated with synthetic agents like calcium antagonists or cellular respiration activators, providing a safe alternative

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent converts the common knowledge that amino acids are generally safe and well-tolerated into a benefit, using glutamine's safety profile to avoid the harmful side effects of conventional blood flow enhancers while maintaining therapeutic effectiveness

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Effectively increases blood flow in capillary vessels without causing side effects like low systemic blood pressure, enhancing vital functions and treating conditions like dementia and muscle fatigue.

Implementation Method 1

The changes in blood flow in the capillary vessels after the administration of glutamine were carefully observed

Methodology Applied

Scientific EffectMetabolism:

Implementation Method 2

Administering glutamine within a specific dosage range (25 mg/kg to 150 mg/kg body weight) along with pyrrolidone carboxylic acid and its derivatives to increase blood flow

Methodology Applied

Scientific EffectSynergistic action:

Data Source

PatentUS7829593B2Glutamine-containing compositions and a method for increasing blood flow using same

Publication Date: 2010.11.09 AJINOMOTO CO INC

AI summary

The present invention provides a glutamine-containing composition which functions to increase blood flow. Glutamine is present in the composition in an amount of 25 mg/kg body weight to 150 mg/kg body weight. By administering the composition to a subject in need thereof, the blood flow in the capillary vessels can be efficiently increased, while inhibiting any side effects such as low blood pressure. The present invention also provides food or feed containing the composition for increasing blood flow.