Glutathione Composition for In Vivo Nitric Oxide Elevation
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Solution Overview
Problem
Existing methods do not effectively increase nitric oxide (NO) concentration in vivo using glutathione, limiting its potential for preventing or ameliorating vascular endothelial malfunction-related symptoms and promoting vasodilation and blood flow.
Innovation Solution
An agent comprising glutathione or its salt as an active ingredient, administered orally or parenterally, to elevate NO concentration and improve vascular function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If glutathione is administered to elevate NO concentration, then vascular function is improved, but the effectiveness is limited under conventional administration methods
Solution Approach 1:
The patent changes the chemical form of glutathione from the conventional reduced form to oxidized glutathione (GSSG) or its derivatives. This parameter change in the molecular state enables more effective elevation of NO concentration in vivo, resolving the limitation of conventional glutathione administration methods while maintaining vascular function improvement benefits
2Reliability
If external NO donors are added in experimental conditions, then vasodilation is induced, but this does not reflect in vivo effectiveness
Solution Approach 1:
The patent enables glutathione itself to serve the dual function of both antioxidant activity and NO concentration elevation without requiring external NO donors. The oxidized glutathione formulation autonomously elevates endogenous NO levels in vivo, eliminating the need for external NO donor addition and reflecting true in vivo effectiveness rather than experimental artifact
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The agent effectively elevates NO concentration, providing short-term and long-term benefits for preventing or ameliorating vascular endothelial malfunction, enhancing exercise performance, improving muscle metabolism, and improving skin quality, memory, and learning ability.
Implementation Method 1
An agent for elevating nitric oxide (NO) concentration comprising glutathione or a salt thereof as an active ingredient, in which prevention or amelioration of a vascular endothelial malfunction-related symptom, or vasodilation and blood flow-promoting effects through a higher NO concentration elevating action in vivo can be expected
Data Source
AI summary
An agent for elevating nitric oxide (NO) concentration comprising glutathione or a salt thereof as an active ingredient; an agent for elevating NO concentration comprising glutathione or a salt thereof as an active ingredient for preventing or ameliorating a vascular endothelial malfunction-related symptom, or dilating blood vessels or promoting blood flow by elevating NO concentration; and a method for elevating NO concentration by ingesting glutathione or a salt thereof.