Glutathione Transdermal Patch Liposomal Delivery

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

There is a need for an effective transdermal delivery system for glutathione to reduce nausea in patients, particularly one that avoids common side effects associated with oral administration and provides localized and sustained absorption.

Innovation Solution

A transdermal delivery system comprising a liposomal formulation and a latex-free hypoallergenic adhesive patch, which includes glutathione, vitamins, and other active ingredients, allowing for absorption through the skin without the need for injections or oral supplementation, minimizing side effects and providing sustained release over 24 to 48 hours.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If glutathione is administered orally, then it can be delivered to patients, but it causes stomach upset and allergic reactions

Engineering Contradiction:

Improveease of administrationVSAvoidside effects

Core Design Contradiction:

Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The patent uses the skin as an intermediary delivery route instead of oral administration. The transdermal patch delivers glutathione through the skin barrier, bypassing the gastrointestinal tract and avoiding stomach upset and allergic reactions while still achieving systemic delivery of the active ingredient

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces the oral ingestion mechanism with a transdermal delivery mechanism. Instead of swallowing pills or capsules that pass through the digestive system, the medication is delivered through a patch that uses transdermal absorption to enter the bloodstream directly

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Object-affected harmful factors

If a transdermal delivery system is used, then side effects are minimized, but the formulation complexity increases

Engineering Contradiction:

Improveside effectsVSAvoidformulation complexity

Core Design Contradiction:

Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

The patent employs a composite liposomal formulation containing glutathione, vitamins, and other active ingredients encapsulated in liposomes. This composite structure allows for sustained release and improved skin penetration while maintaining a manageable patch design that adheres to the skin and delivers multiple components simultaneously

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The transdermal patch is designed to perform multiple functions: it delivers glutathione for nausea reduction, provides vitamins for overall health support, and offers sustained release over time. This multi-functionality is achieved within a single integrated patch formulation that combines multiple active ingredients

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Reliability

If glutathione is delivered systemically, then nausea is reduced, but the absorption is not localized or sustained

Engineering Contradiction:

ImproveeffectivenessVSAvoidduration of absorption

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent implements sustained release through the liposomal formulation and controlled transdermal absorption. The patch maintains continuous delivery of glutathione over an extended period, ensuring reliable and sustained therapeutic effects rather than transient absorption spikes followed by rapid clearance

Inventive Principle:

Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system effectively reduces nausea, improves sleep, increases energy and concentration, reduces wrinkles and joint pain, and enhances skin moisture retention, while avoiding common side effects like stomach upset and allergic reactions, thereby providing preventive care against aging and potential life-threatening illnesses.

Implementation Method 1

Methodology Applied

Scientific EffectTransdermal absorption: Permeation

Data Source

PatentUS10548830B2Composition for transdermal delivery of glutathione

Publication Date: 2020.02.04 GLUTATHERAPY LLC

AI summary

A transdermal formulation which can be applied to the skin, body, face using a combination of glutathione, in the presence of a wide range of active components while increasing permeation of active antioxidant agents. A therapeutically effective amount creates in the patient (i) regulation of sleep, (ii) increased energy during awake periods, (iii) improved concentration during awake periods, (iv) reduction of facial wrinkles, and (v) reduction of joint and muscular pain with increases by at least 10 percent of the ability of skin to retain moisture and totally absorb the glutathione without requiring injection or oral supplementation of the glutathione.