Glycerol Derivative for Wrinkle Reduction and Skin Moisture
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Solution Overview
Problem
Conventional wrinkle improving agents do not provide a satisfactory wrinkle improvement effect and can cause undesirable side reactions, necessitating a new ingredient with enhanced safety and efficacy.
Innovation Solution
A glycerol derivative with a specific structure, expressed by Formulas (1) and/or (2), is used as a wrinkle improving agent, offering high safety and excellent anti-wrinkle action, which is incorporated into an external skin composition for improved wrinkle reduction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional wrinkle improving agents (moisturizing means using polymers like mucopolysaccharide or collagen) are used, then skin moisture is improved, but wrinkle improvement effect is insufficient
Solution Approach 1:
The patent changes the chemical structure parameters by introducing a specific glycerol derivative with a cyclohexyl group and ether linkage, replacing conventional polymers. This structural modification enables the compound to penetrate deeper into the skin and activate specific pathways (NF-kB, MAPK) that directly address wrinkle formation mechanisms, thereby achieving both moisture improvement and reliable wrinkle reduction.
Solution Approach 2:
The patent combines multiple functional mechanisms in a single compound: moisturizing action (like conventional polymers), anti-oxidation (through specific chemical structure), and direct wrinkle reduction (via NF-kB and MAPK pathway inhibition). This composite approach integrates the benefits of multiple ingredients into one active substance, resolving the insufficiency of conventional single-function agents.
2Reliability
If conventional wrinkle improving agents are used at effective concentrations, then wrinkle improvement effect is achieved, but undesirable side reactions occur
Solution Approach 1:
The patent modifies the chemical parameters by using a glycerol derivative with specific functional groups (cyclohexyl ether structure) that alter the compound's interaction with skin cells. This structural change allows the agent to achieve wrinkle improvement at lower concentrations without activating harmful pathways, thereby reducing side reactions while maintaining efficacy.
Solution Approach 2:
The patent converts the potential harm of high-concentration active ingredients into benefit by using a molecule that inherently has low toxicity but high specificity. The glycerol derivative structure allows it to selectively target wrinkle-related pathways (NF-kB, MAPK) without causing widespread cellular stress or adverse reactions, turning what could be harmful high-dose therapy into safe low-dose treatment.
3Reliability
If multiple ingredients are proposed for wrinkle improvement (retinol, amino acids, macromolecules, vitamins), then comprehensive wrinkle addressing is attempted, but formulation complexity increases
Solution Approach 1:
The patent creates a universal agent that performs multiple functions simultaneously: it acts as a moisturizer, antioxidant, and direct wrinkle reducer through a single glycerol derivative molecule. This multi-functionality eliminates the need for complex multi-ingredient formulations, as one compound addresses the same wrinkle mechanisms that previously required combinations of retinol, amino acids, macromolecules, and vitamins.
Solution Approach 2:
The patent merges the functions of multiple conventional ingredients into a single integrated molecule. The glycerol derivative combines the moisturizing properties of hyaluronic acid, the antioxidant activity of vitamins, and the wrinkle-reducing action of retinol into one unified compound, thereby simplifying the formulation while maintaining comprehensive wrinkle addressing capability.
Data Source
AI summary
The object is to provide a wrinkle improving agent having an excellent wrinkle improving effect. A compound expressed by the following Formulas (1) and/or (2) is used as an active ingredient of a wrinkle improving agent.(In Formulas (1) and (2), R and R′ independently represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R″ represents an alkylene group having 1 to 3 carbon atoms, and n represents a number of 0 or 1.)