Monoalkyl Glycerol Ether Stabilizer Solubility
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Solution Overview
Problem
Existing stabilizer compositions based on monoalkyl glycerol ethers and aromatic alcohols face limitations in solubility in water, leading to unreliable protection against microbial growth in aqueous products, as they often exceed permissible concentrations and have compatibility issues with other ingredients, especially in cosmetic and pharmaceutical applications.
Innovation Solution
A stabilizer composition comprising a mixture of 1- or 2-(C1- to C24-) glycerol monoalkyl ethers with a combination of at least two different aromatic alcohols from the groups of aryloxyalkanols, arylalkanols, and oligoalkanol aryl ethers, where the alcohols belong to different groups, enhancing solubility and effectiveness while avoiding irritative effects and compatibility issues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If combinations of monoalkyl glycerol ethers with aromatic alcohol are used as stabilizer compositions, then broad-spectrum antimicrobial protection is achieved, but solubility in water is limited and permissible concentration limits are exceeded
Solution Approach 1:
The aromatic alcohol component is segmented into at least two different aromatic alcohols from different groups (aryloxyalkanol, arylalkanol, and/or oligoalkanol aryl ether). This segmentation allows each alcohol to contribute differently to solubility and antimicrobial activity, enabling the composition to achieve broad-spectrum protection while maintaining water solubility within permissible limits.
Solution Approach 2:
The invention changes the compositional parameters by specifying that the aromatic alcohols must belong to different chemical groups and defining specific concentration ranges (0.01-5% wt for glycerol ether, 0.01-3% wt for each aromatic alcohol). These parameter changes optimize both solubility and antimicrobial effectiveness while staying within regulatory limits.
2Reliability
If higher concentrations of monoalkyl glycerol ether and aromatic alcohol are used to improve antimicrobial effectiveness, then broad-spectrum activity is enhanced, but compatibility issues with other ingredients arise and permissible limits are exceeded
Solution Approach 1:
The invention optimizes concentration parameters to balance effectiveness and compatibility. By limiting glycerol monoalkyl ether to 0.01-5% wt and each aromatic alcohol to 0.01-3% wt, the composition achieves broad-spectrum antimicrobial activity while maintaining compatibility with cosmetic and pharmaceutical ingredients and avoiding skin irritation.
Solution Approach 2:
The stabilizer composition is formulated as a composite system combining glycerol monoalkyl ether with multiple aromatic alcohols from different chemical groups. This composite approach creates synergistic effects that enhance antimicrobial broad-spectrum activity while the diversified chemical structure improves compatibility with other formulation ingredients.
3Device complexity
If single aromatic alcohol is used in combination with monoalkyl glycerol ether, then formulation is simple, but broad-spectrum activity against bacteria, yeasts, and moulds is insufficient
Solution Approach 1:
The aromatic alcohol component is divided into at least two different alcohols from different chemical groups (aryloxyalkanol, arylalkanol, and/or oligoalkanol aryl ether). This segmentation targets different microbial structures and mechanisms, enabling effective action against bacteria, yeasts, and moulds simultaneously while maintaining manageable formulation complexity.
Solution Approach 2:
The combination of multiple aromatic alcohols from different groups provides multi-functionality, where each alcohol contributes to different aspects of broad-spectrum antimicrobial activity. This universal approach ensures effectiveness against diverse microorganisms including gram-positive and gram-negative bacteria, yeasts, and moulds.
Data Source
AI summary
A stabilizer composition having (a) one or more 1- or 2-(C1- to C24-alkyl) glycerol ethers (glycerol monoalkyl ethers) and (b) a mixture of at least two different aromatic alcohols (b1, b2) chosen from the groups of i) aryloxyalkanols, ii) arylalkanols and iii) oligoalkanol aryl ethers, where the two different aromatic alcohols belong to different groups i), ii) and iii).