Glycerol-Sebacate Polymer Sustained Release in Dermocosmetics

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Solution Overview

Problem

Conventional dermocosmetic compositions lack a carrier or controlled release vehicle that provides additional skin benefits beyond the active ingredients, limiting their effectiveness in skin health and regeneration.

Innovation Solution

Incorporating a glycerol-sebacate component with repeating units of (glycerol sebacate) into dermocosmetic compositions, which serves as a sustained release polymer, therapeutic delivery matrix, or elastomeric film, enhancing skin care by supporting cell growth, proliferation, and molecular health, and providing controlled release of active ingredients.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional dermocosmetic compositions use traditional carriers or controlled release vehicles, then active ingredient delivery is achieved, but additional skin benefits are not provided

Engineering Contradiction:

Improveskin health benefitsVSAvoidmulti-functionality of carrier

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The glycerol-sebacate component serves multiple functions simultaneously: it acts as a controlled release vehicle for active ingredients, provides intrinsic skin health benefits through cell growth support and proliferation, and offers protective functions. This multi-functionality resolves the contradiction by making the carrier itself therapeutically beneficial rather than merely a delivery mechanism.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent merges the carrier function with therapeutic function by incorporating glycerol-sebacate, which combines the role of a controlled release vehicle with the biological activities of supporting cell growth, proliferation, and molecular health. This consolidation eliminates the need for separate therapeutic agents in the carrier system.

Inventive Principle:

Principle #5Merging (Combining)

2Duration of action of moving object

If glycerol-sebacate is used as a sustained release polymer, then controlled release of active ingredients is achieved, but formulation complexity increases

Engineering Contradiction:

Improvesustained release capabilityVSAvoidformulation complexity

Core Design Contradiction:

Duration of action of moving objectVSDevice complexity

Solution Approach 1:

The patent utilizes the inherent properties of glycerol-sebacate, a biodegradable polymer with specific molecular weight ranges, to achieve sustained release. By selecting appropriate polymer parameters (molecular weight, composition ratios), the formulation achieves controlled release without requiring complex multi-component systems or sophisticated delivery mechanisms.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If active ingredients are delivered in high concentrations, then therapeutic effectiveness is improved, but skin irritation and harmful effects increase

Engineering Contradiction:

Improvetherapeutic effectivenessVSAvoidskin irritation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The glycerol-sebacate polymer acts as an intermediary matrix that encapsulates and gradually releases active ingredients. This mediation allows therapeutic concentrations to be achieved over time without the acute irritation that would result from high initial concentrations, as the polymer controls the release kinetics and protects the skin from sudden exposure to high drug levels.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The glycerol-sebacate component improves skin health by delivering active ingredients in a controlled manner, promoting regeneration, healing, and maintaining skin integrity while avoiding oily feel and providing antimicrobial and UV protection, thus enhancing the efficacy of dermocosmetic products.

Implementation Method 1

the glycerol-sebacate component itself is also beneficial to the skin and may serve as a sustained release polymer, therapeutic delivery matrix, or elastomeric film

Methodology Applied

Scientific EffectControlled release:

Implementation Method 2

enhancing skin care by supporting cell growth, proliferation, and molecular health

Methodology Applied

Scientific EffectCell growth and proliferation:

Implementation Method 3

providing antimicrobial and UV protection

Methodology Applied

Scientific EffectAntimicrobial activity:

Implementation Method 4

providing antimicrobial and UV protection

Methodology Applied

Scientific EffectUV protection: Absorption (EM radiation)

Data Source

PatentUS10918724B2Dermocosmetic compositions including glycerol-sebacate

Publication Date: 2021.02.16 SECANT GROUP LLC

AI summary

A method of forming a skin care product includes combining at least one additive including at least one active ingredient with at least one glycerol-sebacate component having repeating units of (glycerol sebacate), water, a co-solvent, and at least one of an emulsifier, a surfactant, and a bodying agent to form the skin care product. A dermocosmetic composition includes at least one additive including at least one active ingredient and at least one glycerol-sebacate component having repeating units of (glycerol sebacate). A method of skin care includes applying a dermocosmetic composition to a skin surface.