Glycol-Rich Spore Formulations to Prevent Agglomeration and Odor
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Solution Overview
Problem
Aqueous formulations of bacterium spores tend to decompose, agglomerate, and develop undesirable odors, making them difficult to handle and spray effectively.
Innovation Solution
The process involves dispersing bacterium spores in an aqueous continuous phase with a glycol content exceeding the water content, using a weight ratio of glycol to water between 4:1 to 1.2:1, and optionally adding surfactants and thickeners to create stable formulations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If aqueous formulations of bacterium spores are prepared, then the formulations are easy to prepare and apply, but they tend to decompose, agglomerate, and develop undesirable odors
Solution Approach 1:
The patent changes the chemical composition parameters of the formulation by incorporating specific glycols (ethylene glycol, propylene glycol, butylene glycol) and surfactants at controlled concentrations. This modifies the physical-chemical environment to prevent spore decomposition and agglomeration while maintaining ease of preparation and application.
Solution Approach 2:
The patent creates a composite formulation system combining bacterium spores with glycols and surfactants. This composite structure provides both the biological activity of the spores and the stabilizing properties of the glycol-surfactant matrix, preventing decomposition and agglomeration while maintaining ease of use.
2Ease of operation
If aqueous formulations of bacterium spores are prepared, then the formulations can be easily applied, but they develop undesirable odors
Solution Approach 1:
The patent modifies the formulation's chemical composition by adding specific glycols and surfactants that alter the odor profile while maintaining ease of application. The glycols act as odor-masking agents and the surfactants help stabilize the spore suspension, preventing conditions that lead to odor development.
3Ease of manufacture
If bacterium spores are dispersed in aqueous phase, then the formulations are simple to prepare, but they tend to agglomerate
Solution Approach 1:
The patent introduces glycols and surfactants as intermediary substances between the bacterium spores and the aqueous phase. These intermediaries reduce surface tension and prevent direct spore-spore contact that leads to agglomeration, while maintaining the simplicity of the preparation process.
Solution Approach 2:
The patent changes the physical-chemical parameters of the dispersion medium by incorporating glycols and surfactants. This modifies the interfacial properties and electrostatic environment to prevent spore agglomeration while keeping the formulation easy to prepare.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting formulations are stable, non-agglomerating, and easy to handle, with minimal odor development, allowing for homogeneous distribution and effective application.
Implementation Method 1
b) An aqueous continuous phase comprising at least one glycol, wherein said bacterium spores are dispersed in the continuous phase
Implementation Method 2
An aqueous continuous phase comprising at least one glycol
Implementation Method 3
c) optionally at least one surface active compound S
Implementation Method 4
c) optionally at least one surface active compound S
Implementation Method 5
d) Optionally adding at least one thickener
Data Source
AI summary
Process for making liquid dispersion formulations comprisinga) at least one type of bacterium spores,b) an aqueous continuous phase comprising at least one glycol, wherein said glycol is comprised in the formulation in a weight amount that exceeds the weight amount of water,c) optionally at least one surface active compound S, andd) optionally further auxiliaries,A. providing a solid powder of Bacterium spores,B1. dispersing said spores in a continuous phase comprising at least one glycol, wherein the weight ratio of said at least one glycol to water is below or equal to 1:1,B2. adding further glycol to the dispersion obtained in step B1. to obtain a ratio of said at least one glycol to water from 4:1 to 1.2:1,C. adding at least one surfactant S,D. optionally adding at least one thickener,E. optionally adding further auxiliaries,wherein steps C, D and E can be carried out at any time during the process.