Antimicrobial Glycolipid Formulation With Alpha-Cyclodextrin Stability

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Solution Overview

Problem

Existing antimicrobial glycolipids formulations in water-based products face stability issues such as turbidity, cloudiness, and emulsion disturbances, limiting their broad application in foods, beverages, cosmetics, and medical products.

Innovation Solution

Incorporating alpha-cyclodextrin as a stabilizer with antimicrobial glycolipids in a specific ratio, enhancing compatibility and maintaining antimicrobial efficacy in water-based products.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If antimicrobial glycolipids are used at higher concentrations in water-based products, then antimicrobial efficacy is improved, but formulation stability deteriorates (turbidity and emulsion disturbances occur)

Engineering Contradiction:
Improveantimicrobial efficacyVSAvoidformulation stability
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent introduces a specific stabilizer as an intermediary substance that mediates between the antimicrobial glycolipid and the water-based formulation. This stabilizer prevents the direct interaction between glycolipids and water that causes turbidity and emulsion disturbance, allowing higher glycolipid concentrations to be maintained without compromising formulation stability.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the formulation parameters by adding a stabilizer component and optimizing the concentration ratio of glycolipid to stabilizer. This parameter modification enables the system to maintain both high antimicrobial efficacy (through sufficient glycolipid concentration) and formulation stability (through the stabilizing effect of the added component).

Inventive Principle:
Principle #35Parameter changes

2Reliability

If conventional preservatives are used, then microbial contamination is controlled, but health safety deteriorates (toxicity, allergenicity, carcinogenicity)

Engineering Contradiction:
Improvepreservative effectVSAvoidhealth safety
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical composition parameter by replacing conventional synthetic preservatives with naturally derived antimicrobial glycolipids. This substitution maintains the preservative effect while eliminating or reducing the harmful factors associated with traditional preservatives such as toxicity, allergenicity, and carcinogenicity.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs naturally derived glycolipids that are biodegradable and break down into harmless substances, replacing persistent synthetic preservatives. These natural compounds provide effective antimicrobial action but decompose over time, eliminating long-term accumulation and associated health risks.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Alpha-cyclodextrin stabilizes antimicrobial glycolipids, preventing turbidity and emulsion disturbances, allowing long-term stability and broad application in various water-based products while retaining antimicrobial activity.

Implementation Method 1

Incorporating alpha-cyclodextrin as a stabilizer with antimicrobial glycolipids in a specific ratio, enhancing compatibility and maintaining antimicrobial efficacy in water-based products

Methodology Applied
Scientific EffectInclusion complex formation: Absorption (physical)

Data Source

PatentEP3442335B1Formulation systems for antimicrobial glycolipids
Publication Date: 2025.12.03 IMD NATURAL SOLUTIONS GMBH
  • EP3442335B1 patent drawing
  • EP3442335B1 patent drawing
  • EP3442335B1 patent drawing

AI summary

The invention relates to a composition comprising one or more antimicrobial glycolipids and one or more formulation stabilizers. The invention also relates to methods of preparing the compositions and their application in water containing food, beverage, cosmetic, home care and medical products.