GM-CSF Hydrogel Composition for Chronic Wound Healing
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Solution Overview
Problem
Non-healing wounds, such as chronic ulcers, are a significant health issue affecting a substantial portion of the population, particularly in elderly or diabetic individuals, and current treatments lack effective, well-established advanced wound care therapies.
Innovation Solution
A pharmaceutical composition comprising granulocyte-macrophage colony-stimulating factor (GM-CSF), sucrose octasulfate (SOS), and hyaluronic acid (HA) is applied topically to wounds, enhanced by a roller tool with protrusions to penetrate intracutaneously, promoting optimal wound healing through the sequential phases of hemostasis, inflammation, proliferation, and remodeling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If standard treatment modalities (debridement, infection control, mechanical compression) are used for chronic wounds, then basic wound care is provided, but healing is insufficient and advanced therapies are required
Solution Approach 1:
The patent combines three distinct therapeutic agents (GM-CSF, sucrose octasulfate, and hyaluronic acid) into a single integrated pharmaceutical composition. GM-CSF recruits inflammatory cells, sucrose octasulfate enhances collagen production and stabilizes the matrix, and hyaluronic acid provides wound bed preparation and moisture retention. This merging of multiple functions into one composition resolves the contradiction by providing comprehensive advanced therapy while simplifying the treatment protocol.
Solution Approach 2:
The pharmaceutical composition uses a composite formulation where sucrose octasulfate and hyaluronic acid serve as both therapeutic agents and formulation excipients. This composite approach allows the composition to provide multiple therapeutic effects simultaneously while maintaining stability and deliverability, thereby improving healing effectiveness without requiring multiple separate complex treatments.
2Reliability
If advanced wound care therapies are developed to improve healing outcomes, then healing effectiveness increases, but evidence for effectiveness remains weak and treatment selection is complex
Solution Approach 1:
The pharmaceutical composition is designed with multi-functionality to address various aspects of wound healing simultaneously. The combination of GM-CSF (inflammatory cell recruitment), sucrose octasulfate (collagen synthesis and matrix stabilization), and hyaluronic acid (wound bed preparation and moisture management) creates a universal treatment that can be applied to different types of chronic wounds including diabetic foot ulcers, venous stasis ulcers, and pressure ulcers, thereby improving both effectiveness and adaptability.
3Ease of operation
If topical composition is applied to wound surface only, then application is simple, but penetration to intracutaneous and subcutaneous layers is insufficient
Solution Approach 1:
The roller tool with protrusions acts as an intermediary device that bridges the gap between simple topical application and deep tissue delivery. The protrusions mechanically facilitate penetration of the composition through the epidermis into the intracutaneous and subcutaneous layers, while the composition itself (with its hydrogel formulation) serves as a mediator that maintains stability during application and ensures controlled release at the target site.
Solution Approach 2:
The invention replaces complex injection or surgical delivery systems with a simplified mechanical roller application system. The roller with protrusions provides sufficient mechanical force for topical-penetrative delivery without requiring needles, syringes, or surgical intervention, thereby maintaining ease of operation while achieving the necessary penetration depth for effective treatment.
Data Source
Figure 1
AI summary
The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor (GM-CSF), sucrose octasulfate including salts thereof, and hyaluronic acid for the treatment, pre-emptive treatment or prophylaxis of ulcers, wounds and other injuries to the skin or membranes of the body. Other aspects of the invention are methods of treatment or prevention using the compositions described, as well as an application device for use in the methods provided.