Pressurized gNO Delivery System for Wound Bioburden Reduction
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Solution Overview
Problem
Current treatments for skin and soft tissue infections (SSTIs) and osteomyelitis are inadequate in effectively reducing bioburden and promoting wound healing due to uncertainties in the timing, concentration, pressurization, and site of Nitric Oxide (NO) administration.
Innovation Solution
A gaseous Nitrous Oxide (gNO) delivery system that includes a source of gNO functionally coupled to a subject interface unit, with a gas flow regulator and pressure regulator, delivering gNO at specific parameters (0.15 ATM to 1.0 ATM, 0.1 liters/minute to 1.0 liters/minute, and 1.0% concentration) for 30 minutes to 120 minutes, equipped with sensors and a flushing mechanism to ensure continuous and controlled exposure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Nitric Oxide is administered to reduce bioburden and promote wound healing, then pathogenic organisms are reduced and tissue repair is accelerated, but the timing, concentration, pressurization, and site of administration are poorly understood and difficult to control
Solution Approach 1:
The patent applies parameter changes by systematically varying and optimizing multiple administration parameters including concentration (1-100% NO in gas mixture), pressure (0.1-2.0 ATM gauge pressure), flow rate (0.01-10.0 liters/minute), and duration (1-180 minutes) to achieve reliable therapeutic effects while maintaining control over the complex delivery process
Solution Approach 2:
The delivery system integrates multiple functions into a single device including gas mixture preparation, pressure regulation, flow control, timing management, and wound site delivery, thereby reducing the complexity of coordinating multiple separate administration components
2Object-affected harmful factors
If gaseous Nitric Oxide is delivered at high concentration and pressure to effectively reduce infection, then pathogenic organisms are significantly reduced, but cell viability may be compromised
Solution Approach 1:
The system dynamically adjusts administration parameters based on treatment phase and wound characteristics, using higher concentrations (10-100%) and pressures (0.5-2.0 ATM) during early debridement phases to maximize pathogen reduction, then transitioning to lower parameters during later healing phases to protect viable cells and promote tissue regeneration
Solution Approach 2:
The treatment protocol employs periodic cycles of high-concentration NO delivery followed by lower-concentration phases, with treatment durations ranging from 1 to 180 minutes in staged intervals, allowing sufficient time for pathogen elimination while providing recovery periods that protect host cell viability
3Reliability
If Nitric Oxide is administered for extended periods to ensure complete bioburden reduction, then infection is thoroughly treated, but treatment time and resource consumption increase
Solution Approach 1:
The system incorporates feedback mechanisms including visual indicators (LED lights) that monitor and communicate treatment phase status, automated timing controls that manage delivery intervals, and pressure/flow sensors that verify proper administration, enabling clinicians to confidently terminate treatment at optimal points without excessive duration while ensuring complete bioburden reduction
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively reduces bioburden and promotes wound healing by delivering gNO under therapeutic parameters, significantly reducing pathogenic organisms and accelerating tissue repair without compromising cell viability.
Implementation Method 1
delivering pressurized gNO to a subject
Data Source
AI summary
Embodiments of the present disclosure provide systems and devices for delivering gaseous Nitrous Oxide (gNO) under therapeutic parameters to reduce infection in a subject. Certain embodiments include devices and systems for delivering pressurized gNO to reduce bioburden and promote healing in the wounds of subjects having various disease conditions, including skin and soft tissue infections (SSTIs) and osteomyelitis. In some embodiments, the present disclosure provides portable wound healing devices for delivering pressurized gNO to the site of a wound to treat various disease conditions in a subject.